Danger signals in stroke and their role on microglia activation after ischemia

Therapeutic Advances in Neurological Disorders
Eileen GülkeTim Magnus

Abstract

Ischemic stroke is a major cause of death. Besides the direct damage resulting from oxygen and glucose deprivation, sterile inflammation plays a pivotal role in increasing cellular death. Damaged-associated molecular patterns (DAMPs) are passively released from dying cells and activate the innate immune system. Thus, they take part in the direct and rapid activation of the inflammatory response after stroke onset. In this review the role of the most important DAMPs, high mobility group box 1, heat and cold shock proteins, purines, and peroxiredoxins, are addressed. Moreover, intracellular pathways activated by DAMPs in microglia are illuminated.

References

Jan 1, 1994·Annual Review of Immunology·P Matzinger
Jul 12, 2002·Nature·Paola ScaffidiMarco E Bianchi
Oct 9, 2003·The EMBO Journal·Tiziana BonaldiMarco E Bianchi
Apr 2, 2005·Nature Reviews. Immunology·Michael T Lotze, Kevin J Tracey
May 18, 2005·Neuroscience Letters·Mei-Hua JinDong-Seok Lee
Apr 26, 2006·Circulation·Gokhan YilmazD Neil Granger
Jun 16, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jung-Bin KimJa-Kyeong Lee
Oct 13, 2006·Journal of Leukocyte Biology·Marco E Bianchi
Oct 13, 2006·Journal of Leukocyte Biology·Ingrid E DumitriuPatrizia Rovere-Querini
Nov 1, 2006·Biochemical Society Transactions·A M PlanasA Chamorro
Apr 6, 2007·Nature·Schuichi KoizumiKazuhide Inoue
May 3, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zhen ZhengMidori A Yenari
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sung-Chun TangMark P Mattson
Nov 15, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jianhua QiuMichael A Moskowitz
Nov 15, 2008·Shock·Thiruma V ArumugamTrent M Woodruff
Mar 7, 2009·Stroke; a Journal of Cerebral Circulation·Mathias GelderblomTim Magnus
Mar 24, 2009·Annual Review of Immunology·Fabio MartinonJürg Tschopp
Apr 22, 2009·The Journal of Clinical Investigation·Matthew C HymanDavid J Pinsky
Sep 16, 2009·Archives of Neurology·Diederik van de BeekPaul J Nederkoorn
Jan 16, 2010·Stroke; a Journal of Cerebral Circulation·Xinhua ZhanFrank R Sharp
Jun 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Huan YangKevin J Tracey
Oct 23, 2010·Biochemical and Biophysical Research Communications·Fumie KonoedaAkihiko Yoshimura
Jan 12, 2011·Annual Review of Immunology·Ulf Andersson, Kevin J Tracey
Jan 27, 2011·Anatomy & Cell Biology·Wendy C HuangMidori A Yenari
Jul 9, 2011·Nature Medicine·Costantino Iadecola, Josef Anrather
Jul 23, 2011·Journal of Neurochemistry·Jonathan D VerrierEdwin K Jackson
Dec 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Olivier PascualAlain Bessis
Jan 17, 2012·Inflammopharmacology·Nuri KimMidori A Yenari
May 23, 2012·Nature Medicine·Takashi ShichitaAkihiko Yoshimura
Jun 8, 2012·Nature Medicine·Lidia Garcia-Bonilla, Costantino Iadecola
Dec 4, 2012·Stroke; a Journal of Cerebral Circulation·Juliane SchulzeKyra Becker
Dec 5, 2012·Molecular Immunology·Emilie VenereauMarco E Bianchi
Dec 21, 2012·Neuropathology and Applied Neurobiology·D BocheJ A R Nicoll
Jan 5, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Sung-Chun TangJiann-Shing Jeng
Jan 12, 2013·Science·Adriano AguzziMariko L Bennett
Jan 15, 2013·Journal of Neuroinflammation·Helena W Morrison, Jessica A Filosa

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Citations

Mar 21, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kristy A Zera, Marion S Buckwalter
Apr 14, 2020·Stroke; a Journal of Cerebral Circulation·Xiaoxiao TanYa Hua
Jul 25, 2019·Stroke and Vascular Neurology·Shengxiang Zhang
Jul 12, 2019·Journal of Neuroinflammation·Richard L JayarajGary A Rosenberg
Sep 23, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Laurel O SillerudYi Yang
Oct 26, 2018·Frontiers in Aging Neuroscience·Aarti Mishra, Roberta D Brinton
May 8, 2019·Neuroscience Bulletin·Chuan QinDai-Shi Tian
Sep 22, 2018·International Journal of Molecular Sciences·Berta PuigTim Magnus
Jun 2, 2020·Frontiers in Immunology·Xingping QinSonglin Wu
Jul 8, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Alejandro EspinosaEdda Sciutto
Oct 23, 2019·Signal Transduction and Targeted Therapy·Mrinal K GhoshMalini Basu
Apr 9, 2020·Frontiers in Cellular Neuroscience·Denisa Belov KirdajovaMiroslava Anderova
Sep 12, 2020·Neuromolecular Medicine·Bhakta Prasad Gaire, Ji Woong Choi
Apr 20, 2019·Frontiers in Immunology·Ehsan Javidi, Tim Magnus
Jul 9, 2020·Cells·Ádám MészárosIstván A Krizbai
Jun 20, 2019·Frontiers in Immunology·Franziska M CollmannMathias Hoehn
Aug 9, 2020·Frontiers in Pharmacology·Ana Rita VazDora Brites
Oct 6, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M V Putilina, D V Grishin
Dec 10, 2020·Inflammation and Regeneration·Kento Otani, Takashi Shichita
Dec 21, 2020·Trends in Pharmacological Sciences·Shenpeng R ZhangChristopher G Sobey
Feb 10, 2021·Neurochemical Research·Sanjay KumarBrian Sims
Feb 10, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kazuki HatayamaBarbara S Stonestreet
Oct 16, 2020·Brain Pathology·Daniel BerchtoldAndreas Meisel
Feb 4, 2021·International Journal of Molecular Sciences·Ji Sun HaSeung-Ju Yang
Feb 16, 2021·Frontiers in Aging Neuroscience·Johannes BoltzeMarietta Zille
Oct 12, 2020·Signal Transduction and Targeted Therapy·Mrinal K GhoshMalini Basu
Jul 19, 2020·Journal of Neuroimmunology·Narayanappa AmrutaGregory Bix

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