Dangerous liaisons at the virological synapse

The Journal of Clinical Investigation
Vincent Piguet, Quentin J Sattentau

Abstract

Cell-to-cell viral transmission facilitates the propagation of HIV-1 and human T cell leukemia virus type 1. Mechanisms of cell-to-cell transmission by retroviruses were not well understood until the recent description of virological synapses (VSs). VSs function as specialized sites of immune cell-to-cell contact that direct virus infection. Deciphering the molecular mechanisms of VS formation provides a fascinating insight into how pathogens subvert immune cell communication programs and achieve viral spread.

References

Jan 1, 1992·Virology·D M Phillips, A S Bourinbaiar
Jan 1, 1987·Annals of the New York Academy of Sciences·W E PaulW Tsang
Feb 1, 1987·The Journal of Investigative Dermatology·E TschachlerG Stingl
Oct 29, 1993·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Q J Sattentau, J P Moore
Apr 1, 1998·Nature·J Banchereau, R M Steinman
May 14, 1999·Immunology Today·M RescignoP Ricciardi-Castagnoli
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·D M DavisJ L Strominger
Jun 3, 2000·Annual Review of Immunology·J BanchereauK Palucka
Aug 18, 2001·Cell·A Lanzavecchia, F Sallusto
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y M VyasB Dupont
Dec 12, 2001·Journal of Virology·David C Johnson, Mary T Huber
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anneke EngeringYvette van Kooyk
Jun 7, 2002·Journal of Virology·Carmen P AlvarezRafael Delgado
Jun 8, 2002·Science·Sabine StollRonald N Germain
Aug 23, 2002·The Journal of Investigative Dermatology·Vincent Piguet, Andrew Blauvelt
Sep 28, 2002·Nature Immunology·Dorian B McGavernMichael B A Oldstone
Sep 28, 2002·Nature Immunology·Stuart G TurvilleAnthony L Cunningham
Oct 26, 2002·Science·Michael L Dustin, David R Colman
Nov 6, 2002·The Journal of Cell Biology·David McDonaldThomas J Hope
Nov 26, 2002·Immunological Reviews·Giovanna BossiGillian M Griffiths

❮ Previous
Next ❯

Citations

May 27, 2008·Cellular and Molecular Life Sciences : CMLS·H Garg, R Blumenthal
Jan 12, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Björn D KuhlChen Liang
Mar 5, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Kate L JonesJohnson Mak
Jul 16, 2013·Trends in Microbiology·Lesley A EarlSriram Subramaniam
Aug 20, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Candice WillmonRichard Vile
Jan 9, 2010·Nature Medicine·Kathryn S Jones, Patrick L Green
Apr 8, 2010·Nature Reviews. Microbiology·Mélanie LambotinHeidi Barth
Nov 17, 2004·The Journal of Experimental Medicine·Jean-François ArrighiVincent Piguet
Sep 20, 2008·Current Opinion in HIV and AIDS·Li Wu
Jul 5, 2012·Cold Spring Harbor Perspectives in Medicine·Wesley I Sundquist, Hans-Georg Kräusslich
Nov 3, 2006·Journal of Virology·Marion SourisseauOlivier Schwartz
Apr 3, 2009·Journal of Virology·Martine AubertKeith R Jerome
Feb 10, 2011·Journal of Translational Medicine·Claudia CicalaAnthony S Fauci
Oct 15, 2009·Retrovirology·Isabel PuigdomènechJulià Blanco
Dec 28, 2010·Retrovirology·Björn D KuhlMark A Wainberg
Jun 28, 2008·PLoS Pathogens·Marielle CavroisWarner C Greene
Aug 2, 2012·Marine Drugs·Dana Huskens, Dominique Schols

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.