Danofloxacin (Advocin) reduces the spread of contagious bovine pleuropneumonia to healthy in-contact cattle

Research in Veterinary Science
Otto J B HuebschleR A J Nicholas

Abstract

Contagious bovine pleuropneumonia (CBPP), caused by Mycoplasma mycoides subsp. mycoides SC (MmmSC), is one of the most important diseases of cattle in Sub-Saharan Africa. The live T1/44 vaccine is normally used for its control but produces only transient protection and gives rise to adverse reactions. The present study evaluated the efficacy of danofloxacin (2.5% Advocintrade mark, Pfizer Ltd.) for the treatment of naturally infected cattle and in the prevention of CBPP transmission to in-contact cattle. Adult cattle, taken from a natural outbreak, were placed into two groups of 10 animals and kept on a research farm in paddocks 50m apart. One group was treated with 2.5mg/kg danofloxacin on days 0, 1 and 2; the other group were saline treated. On day 2, 10 CBPP-free, seronegative cattle were placed in contact with each of the two groups. All cattle were monitored for 3.5 months. No differences were seen in clinical improvement of the CBPP-affected cattle treated with danofloxacin compared with the untreated CBPP-affected cattle with approximately half of each group being withdrawn because of CBPP or showing CBPP lesions at post mortem examination. Clinical scores of the two groups were also similar. However cattle kept in conta...Continue Reading

Citations

Feb 19, 2013·Tropical Animal Health and Production·Joshua Orungo OnonoJonathan Rushton
Mar 29, 2011·The Veterinary Journal·Jiuqing XinHui Dong
Jun 22, 2010·Tropical Animal Health and Production·Isabel Gacheri NkandoDeclan McKeever
Apr 22, 2015·Tropical Animal Health and Production·Abubakar SuleimanYaqub Ahmed Geidam
May 12, 2020·Veterinary Pathology·Giovanni Di TeodoroMassimo Scacchia
Oct 3, 2006·The Veterinary Record·Otto HübschleRobin Nicholas
Nov 20, 2012·The Veterinary Record·Robin A J NicholasTim Rowan
Aug 8, 2021·Animals : an Open Access Journal From MDPI·Elizabeth A ClemmonsJohn W Dutton

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