Dantrolene exerts protective activity in double and triple combination with nimodipine, ruthenium red and basilene blue in bilirubin-induced neurotoxicity in cell culture of rats

The International Journal of Neuroscience
Akçahan GepdiremenSelma Düzenli

Abstract

In the present study, dantrolene, nimodipine, basilen blue, and ruthenium red were tested in experimental bilirubin toxicity in cortical cell culture of rats. Neurotoxicity was induced by 10(-4) M bilirubin. Basilen blue in the highest concentration of 10(-4) M was determined as the most protective agent when applied alone. Dantrolene alone was found surprisingly ineffective in all doses tested. But it was found very protective both in double and triple combinations. Nimodipine, basilen blue, and ruthenim red neuroprotective potentials were enhanced by adding dantrolene into the media. Best double combination was determined as dantrolene plus ruthenium red. On the other hand, most useful triple combination was found as dantrolene plus nimodipine plus basilen blue. As a result, dantrolene wasn't found to be effective alone, while it seems most potential compound in combined application in bilirubin-induced neurotoxicity. The importance of calcium intrusion was confirmed in bilirubin-induced neurotoxicity.

References

Sep 1, 1985·Pediatric Research·D SchiffM J Poznansky
Nov 15, 1995·The Biochemical Journal·M J Berridge
Jan 27, 1995·Cell·D E Clapham
Jun 1, 1996·Pediatric Research·T W HansenS I Walaas
Dec 2, 2000·Neurochemistry International·F CavaliereC Volonté
Dec 5, 2000·Journal of Neuroscience Research·C F Chan, S Y Lin-Shiau
Feb 24, 2001·The New England Journal of Medicine·P A DenneryD K Stevenson
Jun 13, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A GepdIremenS Oztaş
Jan 5, 2002·Pediatric Research·Cecília M P RodriguesDora Brites
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J Donald OstrowClaudio Tiribelli
Apr 17, 2003·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Murat KayaIrfan Altuntaş
Oct 13, 2004·Brain Research·Maria Alexandra BritoD Allan Butterfield
Dec 9, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Xiao-Fei ZhouMarilyn E Morris
Mar 17, 2005·The International Journal of Neuroscience·Kakhi BakuridzeAkçahan Gepdiremen

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Citations

Oct 16, 2014·International Journal of Molecular Sciences·Eva HerzfeldChristian Scheller

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