Daptomycin > 6 mg/kg/day as salvage therapy in patients with complex bone and joint infection: cohort study in a regional reference center

BMC Infectious Diseases
Sandrine RouxLyon BJI Study Group

Abstract

Even if daptomycin does not have approval for the treatment of bone and joint infections (BJI), the Infectious Diseases Society of America guidelines propose this antibiotic as alternative therapy for prosthetic joint infection. The recommended dose is 6 mg/kg/d, whereas recent data support the use of higher doses in these patients. We performed a cohort study including consecutive patients that have received daptomycin >6 mg/kg/d for complex BJI between 2011 and 2013 in a French regional reference center. Factors associated with treatment failure were determined on univariate Cox analysis and Kaplan-Meier curves. Forty-three patients (age, 61 ± 17 years) received a mean dose of 8 ± 0.9 mg/kg/d daptomycin, for a mean 81 ± 59 days (range, 6-303 days). Most had chronic (n = 37, 86 %) implant-associated (n = 37, 86 %) BJI caused by coagulase-negative staphylococci (n = 32, 74 %). A severe adverse event (SAE) occurred in 6 patients (14 %), including 2 cases of eosinophilic pneumonia, concomitant with daptomycin Cmin >24 mg/L. Outcome was favorable in 30 (77 %) of the 39 clinically assessable patients. Predictors for treatment failure were age, non-optimal surgery and daptomycin withdrawal for SAE. Prolonged high-dose daptomycin the...Continue Reading

References

Oct 16, 2004·The New England Journal of Medicine·Werner ZimmerliPeter E Ochsner
May 18, 2005·The Journal of Infectious Diseases·Jared A SilvermanJeff Alder
Feb 24, 2009·International Journal of Antimicrobial Agents·Fred C TenoverMelvin P Weinstein
Mar 11, 2009·Clinical Pharmacokinetics·Cornelia B LandersdorferFritz Sörgel
May 14, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sujata M BhavnaniGeorge L Drusano
Dec 31, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S J van HalI B Gosbell
Jun 14, 2012·BMC Infectious Diseases·Jason C GallagherElie Berbari
Jul 17, 2012·The Journal of Antimicrobial Chemotherapy·Jorge Parra-RuizJosé Hernández-Quero
Dec 12, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Douglas R OsmonUNKNOWN Infectious Diseases Society of America
Mar 22, 2013·The Journal of Antimicrobial Chemotherapy·R Andrew SeatonRicardo L Chaves
Jul 6, 2013·Scandinavian Journal of Infectious Diseases·Jason PhillipsJames S Lewis
Nov 20, 2013·Antimicrobial Agents and Chemotherapy·Florent ValourUNKNOWN Lyon BJI Study Group
May 7, 2014·Antimicrobial Agents and Chemotherapy·D MontangeC Chirouze
Aug 20, 2014·The Journal of Antimicrobial Chemotherapy·Cédric Jacqueline, Jocelyne Caillon

❮ Previous
Next ❯

Citations

Jun 28, 2016·BMC Infectious Diseases·Elizabeth D HermsenKenneth C Lamp
Jan 24, 2019·Current Opinion in Infectious Diseases·Matteo BassettiAlessia Carnelutti
Jan 11, 2019·The Journal of Antimicrobial Chemotherapy·Romain BriccaUNKNOWN Lyon Bone and Joint Infection Study Group
Sep 11, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael J SatlinJames H Jorgensen
Feb 8, 2021·The Journal of Antimicrobial Chemotherapy·Romain GarreauUNKNOWN Lyon Bone and Joint Infection Study Group

❮ Previous
Next ❯

Methods Mentioned

BETA
amputation
X-ray

Clinical Trials Mentioned

ISRCTN14244698

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved