Daptomycin-induced Eosinophilic Pneumonia and a Review of the Published Literature

Internal Medicine
Yoshitsugu HigashiYoshihiro Yamamoto

Abstract

A 53-year-old man was admitted to the hospital with a diagnosis of cellulitis and osteomyelitis. Twenty-four days after the initiation of daptomycin and sulbactam/ampicillin, he developed a fever and pulmonary infiltration. Bronchoalveolar lavage revealed a high number of eosinophils, while an intracutaneous test revealed positivity for daptomycin. The patient improved after discontinuing antimicrobial therapy. The plasma daptomycin minimum concentration (Cmin) was elevated (27.4 μg/mL), but plasma protein binding of daptomycin was low (87.8%). Although the pathophysiology of eosinophilic pneumonia remains unclear, antigenic stimulation due to daptomycin accumulation in the alveoli may have caused continuous immune activation.

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Citations

Sep 7, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lindsay M AveryDavid P Nicolau
Jul 3, 2019·BioMed Research International·Yang YeShufang Liang
Apr 24, 2021·Journal of Community Hospital Internal Medicine Perspectives·Vaishnavi RamanSean Shieh

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Methods Mentioned

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Cellulitis (erysipelas) is a recurring and debilitating bacterial infection of the skin and underlying tissue. Discover the latest research on cellulitis here.

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