Daptomycin versus other antimicrobial agents for the treatment of skin and soft tissue infections: a meta-analysis

The Annals of Pharmacotherapy
Ioannis A BliziotisMatthew E Falagas

Abstract

Skin and soft tissue infections (SSTIs) are common in everyday clinical practice. Daptomycin has been shown to achieve very good concentrations in skin and soft tissues. To compare the effectiveness and toxicity of daptomycin with that of other antimicrobials for the treatment of SSTIs. PubMed, Scopus, and the Cochrane Central Register of Controlled Trials were searched for articles published up to March 2009. Comparative studies in which daptomycin was used in the intervention group were included in this meta-analysis. The primary outcome of interest was clinical success; secondary outcomes were microbiologic success, clinical success in subsets with complicated SSTIs (cSSTIs) or infections due to methicillin-resistant Staphylococcus aureus (MRSA), clinical success of daptomycin-versus vancomycin-treated patients, time to clinical cure, treatment-related adverse events, withdrawal from treatment due to toxicity, all-cause mortality, and development of resistance. Four studies were included in the analysis (3 were randomized controlled trials [RCTs]). Vancomycin and semisynthetic penicillins were used in the comparator arm. Three studies reported on patients with cSSTIs. The intention-to-treat (ITT) population was 1557 patients...Continue Reading

References

Mar 1, 1985·Progress in Cardiovascular Diseases·S YusufP Sleight
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
May 17, 2001·Antimicrobial Agents and Chemotherapy·J A SilvermanT Li
Dec 10, 2003·The Journal of Antimicrobial Chemotherapy·Lawrence J EronUNKNOWN Expert panel on managing skin and soft tissue infections
Jul 1, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert D ArbeitUNKNOWN Daptomycin 98-01 and 99-01 Investigators
Oct 9, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin A LipskyUNKNOWN Infectious Diseases Society of America
Jan 11, 2005·Clinical Therapeutics·LilyAnn Jeu, Horatio B Fung
Mar 11, 2005·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Sara E CosgroveYehuda Carmeli
May 27, 2005·Antimicrobial Agents and Chemotherapy·John WeigeltUNKNOWN Linezolid CSSTI Study Group
Oct 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dennis L StevensUNKNOWN Infectious Diseases Society of America
Aug 3, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·H S SaderR N Jones
Nov 23, 2006·Antimicrobial Agents and Chemotherapy·John D SzumowskiKenneth H Mayer
Feb 17, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jörg J RuheAnupama Menon
Oct 24, 2007·Emerging Infectious Diseases·Jennifer K JohnsonMary-Claire Roghmann
Dec 27, 2007·The Canadian Journal of Infectious Diseases = Journal Canadien Des Maladies Infectieuses·John M ConlyElizabeth Miller
Apr 9, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·B I Eisenstein
Mar 4, 2008·Diagnostic Microbiology and Infectious Disease·Mariana CastanheiraHélio S Sader
Jul 30, 2008·Archives of Internal Medicine·Adam L HershRalph Gonzales
Feb 19, 2009·International Journal of Clinical Practice·P E PertelW J Martone

❮ Previous
Next ❯

Citations

Oct 27, 2011·The Journal of Antimicrobial Chemotherapy·Maria Adriana CataldoNicola Petrosillo
Sep 9, 2010·The American Journal of the Medical Sciences·Karen K Kinney
May 11, 2012·Enfermedades infecciosas y microbiología clínica·José Barberán, M Carmen Fariñas
Mar 18, 2011·Dermatologic Therapy·Nina Kaur Hansra, Kanade Shinkai
May 20, 2015·International Journal of Antimicrobial Agents·Christos Tsoulas, Dilip Nathwani
Feb 7, 2013·Journal of Clinical Epidemiology·Anna-Bettina HaidichJohn P A Ioannidis
Aug 16, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Mark BounthavongDavid J Vanness
Nov 26, 2014·World Journal of Emergency Surgery : WJES·Massimo SartelliKuo-Ching Yuan
Aug 17, 2011·Current Opinion in Infectious Diseases·Sebastiaan J van Hal, David L Paterson
Mar 6, 2013·Expert Review of Anti-infective Therapy·Isabella KanzlerAndres Beiras-Fernandez
Dec 20, 2018·World Journal of Emergency Surgery : WJES·Massimo SartelliFausto Catena
Feb 17, 2017·Pediatrics·John BradleyPaula Bokesch

❮ Previous
Next ❯

Software Mentioned

RevMan
Review Manager ( RevMan )
Scopus

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.