Abstract
Hollow fiber membranes (HFMs) are used in blood oxygenators for cardiopulmonary bypass or in next generation artificial lungs. Flow analyses of these devices is typically done using computational fluid dynamics (CFD) modeling HFM bundles as porous media, using a Darcy permeability coefficient estimated from the Blake-Kozeny (BK) equation to account for viscous drag from fibers. We recently published how well this approach can predict Darcy permeability for fiber bundles made from polypropylene HFMs, showing the prediction can be significantly improved using an experimentally derived correlation between the BK constant (A) and bundle porosity (ε). In this study, we assessed how well our correlation for A worked for predicting the Darcy permeability of fiber bundles made from Membrana polymethylpentene (PMP) HFMs, which are increasingly being used clinically. Swatches in the porosity range of 0.4 to 0.8 were assessed in which sheets of fiber were stacked in parallel, perpendicular, and angled configurations. Our previously published correlation predicted Darcy within ±8%. A new correlation based on current and past measured permeability was determined: A = 497ε - 103; using this correlation measured Darcy permeability was within ...Continue Reading
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Citations
Dec 15, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Ryan A OrizondoWilliam J Federspiel
Dec 4, 2019·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Andreas KaeslerJutta Arens
Jun 14, 2019·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Alex J ThompsonRonald B Hirschl
Jan 20, 2021·Journal of Biomechanical Engineering·Daniele DipresaSotirios Korossis