PMID: 2111396Apr 15, 1990Paper

Dark and photoreactivity of 4'-aminomethyl-4,5',8-trimethylpsoralen with T7 phage

Journal of Photochemistry and Photobiology. B, Biology
K TothG Rontó

Abstract

The dark and photoreactions of 4'-aminomethyl-4,5',8-trimethylpsoralen (AMT) with T7 phage were investigated from biological and structural points of view. The dark reaction leads to the structural destabilization of the double helix of the DNA as is shown by optical melting measurements. The genotoxicity of AMT in the dark is comparable with that of known genotoxic drugs as determined by phage inactivation. The photoreaction with UVA light leads to the formation of mono- and di-adducts depending on the wavelength and dose used. Mono- and di-adducts influence DNA stability differently; biologically both types of adducts are genotoxic as measured by action spectra.

References

Oct 1, 1978·Nucleic Acids Research·P K Chatterjee, C R Cantor
Aug 1, 1989·Journal of Photochemistry and Photobiology. B, Biology·G RontóK Módos
Sep 1, 1988·Journal of Photochemistry and Photobiology. B, Biology·K TothD Averbeck
Jan 1, 1987·Photochemistry and Photobiology·O GiaS Marciani Magno
May 1, 1987·Photochemistry and Photobiology·P VignyN E Geacintov
Aug 1, 1984·Photochemistry and Photobiology·F P GasparroR L Edelson
Jan 1, 1984·Biophysics of Structure and Mechanism·K TóthD Aslanian
Jun 5, 1983·Journal of Molecular Biology·J J Dunn, F W Studier
Mar 1, 1981·Photochemistry and Photobiology·R Muller-Runkel, L I Grossweiner
Apr 30, 1980·Biochimica Et Biophysica Acta·C SaletE J Land
Jul 1, 1963·Journal of Molecular Biology·J H STRAUSS, R L SINSHEIMER
Dec 1, 1962·Journal of Molecular Biology·P F DAVISON, D FREIFELDER

❮ Previous
Next ❯

Citations

Mar 1, 1997·Journal of Photochemistry and Photobiology. B, Biology·M D Mamet-Bratley, B Karska-Wysocki
Jan 1, 2010·Journal of Photochemistry and Photobiology. B, Biology·Gabriele MuellerKlaus Braun
Jan 1, 1992·Journal of Photochemistry and Photobiology. B, Biology·G RontóG Csik

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.