DARK Classics in Chemical Neuroscience: Morphine

ACS Chemical Neuroscience
Andrea L DevereauxChristopher W Cunningham

Abstract

As the major psychoactive agent in opium and direct precursor for heroin, morphine is a historically critical molecule in chemical neuroscience. A structurally complex phenanthrene alkaloid produced by Papaver somniferum, morphine has fascinated chemists seeking to disentangle pharmacologically beneficial analgesic effects from addiction, tolerance, and dependence liabilities. In this review, we will detail the history of morphine, from the first extraction and isolation by Sertürner in 1804 to the illicit use of morphine and proliferation of opioid use and abuse disorders currently ravaging the United States. Morphine is a molecule of great cultural relevance, as the agent that single-handedly transformed our understanding of pharmacognosy, receptor dynamics, and substance abuse and dependence disorders.

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Citations

Feb 6, 2019·Pain and Therapy·Irving HaberJo Ann LeQuang
Feb 29, 2020·Expert Opinion on Drug Discovery·Li-Ming ZhouGuang-Fu Yang
May 21, 2020·ChemMedChem·Károly Mazák, Béla Noszál
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Mar 25, 2021·ACS Chemical Neuroscience·István UjváryRoumen Sedefov
Mar 13, 2019·Neuropharmacology·Christopher W CunninghamStephanie U Vold
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Jun 23, 2020·ACS Chemical Neuroscience·Jaime Mella-RaipánGonzalo Recabarren-Gajardo
Aug 14, 2020·ACS Chemical Neuroscience·Anna E RinguetteAaron M Bender
Jul 10, 2019·ACS Chemical Neuroscience·Trevor A TrombleyCraig W Lindsley

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