PMID: 7083115Jul 1, 1982Paper

Dark epithelial cells in preneoplastic lesions of the human respiratory tract

A J Klein-SzantoG Saccomanno


Dark epithelial cells, previously identified in preneoplastic lesions of rat tracheae induced with chemical carcinogens, were observed in similar lesions in human airways and investigated using plastic-embedded material from the lungs of 21 autopsy cases. The lesion types and the percentage of dark cells in their basal layers were as follows: squamous metaplasia without atypia = 13 +/- 3%, squamous metaplasia with slight atypia = 13 +/- 3%, squamous metaplasia with moderate atypia = 26 +/- 5%, squamous metaplasia with severe atypia = 27 +/- 4%, and carcinoma in situ = 34 +/- 11%. Notwithstanding a technical complication caused by differences in fixation and embedding procedures, it was possible to detect an increase in the number of dark cells in human preneoplastic lesions that was directly proportional to the degree of atypia. This increase points to the importance of these cells in neoplastic development and indicates that, regardless of their nature, the number of dark cells can be used as an indicator of the degree of atypia.


Jul 1, 1990·Cell and Tissue Kinetics·N al-SaffarP S Hasleton
Jun 1, 1982·Journal of Oral Pathology·A J Klein-SzantoM Albrecht

Related Concepts

Malignant Neoplasm of Lung
Neoplasms, Experimental
Condition, Preneoplastic
Tracheal Neoplasms

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.