Abstract
The aim of this study was to evaluate the relationship between the virological response to darunavir-based salvage antiretroviral therapy and the darunavir genotypic and virtual inhibitory quotients (gIQ and vIQ, respectively). Thirty-seven HIV-infected patients failing protease inhibitor-based antiretroviral regimens who started salvage therapy containing darunavir-ritonavir were prospectively studied. The primary outcome of the study was a viral load (VL) of <50 copies/ml at week 48. The trough concentrations of darunavir in plasma, the number of darunavir resistance mutations, the change in the 50% inhibitory concentration (IC(50)) of darunavir in the virtual phenotype, and the darunavir gIQ and vIQ were correlated with the virological outcome in regression analyses adjusted by the number of active drugs in the background regimen. The VL was <50 copies/ml in 56.8% of patients at week 48. Changes in the VL were not significantly associated with the darunavir concentration (P = 0.304), the number of darunavir resistance mutations (P = 0.695), or the change in the IC(50) (P = 0.750). However, patients with darunavir vIQs of >or=1.5 had a 12-fold greater chance of achieving a >or=1 log(10) reduction in the VL (odds ratio [OR], 1...Continue Reading
References
Jan 25, 2003·Antimicrobial Agents and Chemotherapy·Anne-Geneviève MarcelinUNKNOWN Genophar Study Group
Oct 9, 2004·HIV Clinical Trials·Ana BarriosVincent Soriano
Nov 25, 2004·Antimicrobial Agents and Chemotherapy·Anne-Geneviève MarcelinVincent Calvez
Apr 28, 2005·Antimicrobial Agents and Chemotherapy·Anne-Geneviève MarcelinVincent Calvez
May 27, 2005·Antimicrobial Agents and Chemotherapy·Sandra De MeyerMarie-Pierre de Béthune
Nov 11, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Mark NelsonMiklos P Salgo
Apr 11, 2006·AIDS·Jolanda G M HoefnagelDavid M Burger
Oct 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph GatheUNKNOWN RESIST-1 Study Group
Oct 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pedro CahnDouglas Mayers
Apr 10, 2007·Lancet·Bonaventura ClotetUNKNOWN POWER 1 and 2 study groups
Jul 10, 2007·Lancet·José Valdez MadrugaUNKNOWN DUET-1 study group
Jul 10, 2007·Lancet·Adriano LazzarinBrian Woodfall
Jul 11, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jean-Michel MolinaUNKNOWN TMC114-C215 Study Group
Oct 30, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Antonio D'AvolioGiovanni Di Perri
Dec 28, 2007·Antimicrobial Agents and Chemotherapy·Daniel Gonzalez de RequenaGiovanni Di Perri
Jun 14, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Martin S HirschDouglas D Richman
Citations
Nov 3, 2010·The Journal of Antimicrobial Chemotherapy·Daniel Gonzalez de RequenaGiovanni Di Perri
Oct 20, 2010·HIV Medicine·J YoungUNKNOWN Swiss HIV Cohort Study
Sep 12, 2012·Antimicrobial Agents and Chemotherapy·Edward P AcostaChristos J Petropoulos
Apr 14, 2010·Antimicrobial Agents and Chemotherapy·Gaik H SoonLawrence Lee
Aug 27, 2009·Therapeutics and Clinical Risk Management·Michael Neely, Andrea Kovacs
Mar 28, 2009·Drugs·Kate McKeageSusan J Keam
Feb 8, 2011·Clinical Pharmacokinetics·Michael N Neely, Natella Y Rakhmanina
Dec 18, 2013·Drugs·Emma D Deeks
Aug 21, 2013·AIDS Research and Treatment·James M MikulaGene D Morse
Jan 13, 2012·Infection·G SterrantinoUNKNOWN ARCA Database Study Group
May 14, 2014·The Journal of Antimicrobial Chemotherapy·M Arab-AlameddineUNKNOWN Swiss HIV Cohort Study
Apr 12, 2014·The Journal of Antimicrobial Chemotherapy·Magali GarciaNicolas Venisse
Jan 26, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·C DelaugerreP de Truchis
May 7, 2011·Fundamental & Clinical Pharmacology·Eric DaillyPascale Jolliet
Jun 25, 2010·British Journal of Clinical Pharmacology·Rob Ter HeineAlwin D R Huitema
Sep 15, 2016·Expert Review of Clinical Pharmacology·Baralee PunyawudhoKiat Ruxrungtham
Oct 22, 2014·International Journal of STD & AIDS·Lucia TaramassoUNKNOWN HIV/HCV Collaborative Liguria Group
Sep 26, 2013·Therapeutic Drug Monitoring·Silvia BaroncelliMarco Floridia
Jun 3, 2021·AIDS·Jeremiah D MomperUNKNOWN IMPAACT P1026s Protocol Team