Dasatinib and nilotinib for imatinib-resistant or -intolerant chronic myeloid leukaemia: a systematic review and economic evaluation.

Health Technology Assessment : HTA
G RogersK Stein

Abstract

Chronic myeloid leukaemia (CML) is a form of cancer affecting the blood, characterised by excessive proliferation of white blood cells in the bone marrow and circulating blood. In the UK, an estimated 560 new cases of CML are diagnosed each year. The purpose of this study was to assess the clinical effectiveness and cost-effectiveness of dasatinib and nilotinib in the treatment of people with imatinib-resistant (ImR) and imatinib-intolerant (ImI) CML. A systematic review of the clinical effectiveness literature, a review of manufacturer submissions and a critique and exploration of manufacturer submissions for accelerated phase and blast crisis CML were carried out and a decision-analytic model was developed to estimate the cost-effectiveness of dasatinib and nilotinib in chronic phase CML. SYSTEMATIC REVIEW METHODS: Key databases were searched for relevant studies from their inception to June 2009 [MEDLINE (including MEDLINE In-Process & Other Non-Indexed Citations), EMBASE, (ISI Web of Science) Conference Proceedings Citation Index and four others]. One reviewer assessed titles and abstracts of studies identified by the search strategy, with a sample checked by a second reviewer. The full text of relevant papers was obtained ...Continue Reading

Citations

Jan 5, 2014·Applied Health Economics and Health Policy·Ursula RochauUwe Siebert
Sep 18, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Elisabetta AbruzzeseRoberto Latagliata
Jul 13, 2013·Applied Health Economics and Health Policy·Ebenezer Tetteh, Stephen Morris
Jan 16, 2018·British Journal of Clinical Pharmacology·Nurgül Özgür Yurttaş, Ahmet Emre Eşkazan
Jul 18, 2014·Archives of Pharmacal Research·A Selen Gurkan-AlpAsuman Sunguroglu
Jun 30, 2019·Anti-cancer Agents in Medicinal Chemistry·Ahmed A ElrashedyMahmoud E S Soliman

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