Dasatinib exacerbates splenomegaly of mice inoculated with Epstein-Barr virus-infected lymphoblastoid cell lines.

Scientific Reports
Ryutaro KotakiAi Kotani

Abstract

Latent infection of Epstein-Barr virus (EBV) is associated with a poor prognosis in patients with B cell malignancy. We examined whether dasatinib, a multi kinase inhibitor, which is broadly used for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia is effective on EBV-positive B cell malignancies, using lymphoblastoid cell lines (LCLs) in vitro and in vivo. As a result, in vitro experiments showed that dasatinib induced cell death of the EBV-LCLs which was not accompanied with a lytic reactivation of EBVs. To evaluate the effectiveness in EBV latency type III represented by immunodeficiency lymphoma, LCL-inoculated immunodeficient NOD/shi-scid/Il2rgnul (NOG) mice were treated with dasatinib. However, in vivo experiments revealed that dasatinib treatment exacerbated tumor cell infiltration into the spleen of LCL-inoculated NOG mice, whereas tumor size at the inoculated site was not affected by the treatment. These results suggest that dasatinib exacerbates the pathogenesis at least in some situations although the drug is effective in vitro. Hence, we should carefully examine a possibility of dasatinib repositioning for EBV+ B cell malignancies.

References

Jul 1, 1997·Journal of Virology·E M MiyashitaD A Thorley-Lawson
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·W KulwichitN Raab-Traub
Oct 13, 1998·Immunity·G J BabcockD A Thorley-Lawson
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A M JosephD A Thorley-Lawson
Jul 17, 2004·Science·Neil P ShahCharles L Sawyers
Oct 29, 2004·Nature Reviews. Cancer·Lawrence S Young, Alan B Rickinson
Dec 13, 2006·ChemMedChem·Zhengying PanJames T Palmer
Jun 3, 2008·The Oncologist·Antonino CarboneGiampietro Dotti
Jan 17, 2009·Nature Reviews. Microbiology·Tessa BergsbakenBrad T Cookson
Feb 3, 2009·Oncogene·R BultemaM Swanson-Mungerson
Apr 28, 2009·Molecular Oncology·Tim P GreenGerard F Costello
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arjan DiepstraSibrand Poppema
Oct 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kathryn T BiegingRichard Longnecker
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Lee A HonigbergJoseph J Buggy
Oct 17, 2013·Nature Reviews. Molecular Cell Biology·Dimitry Ofengeim, Junying Yuan
Sep 19, 2014·The Journal of Pathology·María José MorenoIsolda Casanova
Oct 8, 2014·Advances in Cancer Research·Samit ChatterjeeSridhar Nimmagadda
Dec 30, 2014·Frontiers in Oncology·Kim De VeirmanJo A Van Ginderachter
Feb 3, 2015·Experimental Hematology·Morten P OksvoldWallace Y Langdon
Aug 19, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elisa Ten HackenJan A Burger
Jan 22, 2017·The Journal of Experimental Medicine·Stuart G TangyeEmily S J Edwards
Feb 1, 2017·Nature Reviews. Immunology·Ine JorgensenEdward A Miao
Jun 2, 2017·Journal of Virology·John G KosowiczRichard F Ambinder
Mar 20, 2018·Frontiers in Immunology·Viktor FlemingViktor Umansky
Aug 7, 2019·Proceedings of the National Academy of Sciences of the United States of America·Claudio ScuoppoRiccardo Dalla-Favera

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Citations

Nov 5, 2020·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Hassan Reda Hassan ElsayedRanda El-Gamal
May 29, 2021·Pharmacogenomics·Adrian J GreenAlison Motsinger-Reif
Jul 2, 2021·Journal of Clinical and Experimental Hematopathology : JCEH·Masaharu KawashimaAi Kotani

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Methods Mentioned

BETA
flow cytometry
xenograft
transfection
FACS

Software Mentioned

cellSence

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