Dasatinib in solid tumors

Expert Opinion on Investigational Drugs
Lori C KimEric B Haura

Abstract

Dasatinib is an oral, potent adenosine triphosphate-competitive inhibitor of multiple tyrosine kinases including BCR-ABL, c-KIT, platelet-derived growth factor receptor, and Src family kinases (SFKs). It has gained much attention for its use in chronic myeloid leukemia and for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia. However, dasatinib is also being explored in solid tumors in ongoing Phase I and II clinical trials. The clinical efficacy of dasatinib in a wide variety of solid tumors and important Phase I/II studies utilizing dasatinib and the optimal dosage used in solid tumors. A literature search was conducted using PubMed/MEDLINE, www.clinicaltrials.gov , and the American Society of Clinical Oncology websites to find relevant Phase I/II clinical trials during 1987-2009. The understanding that the biology and mechanism of Src activation in tumors are not well understood and finding the optimal use of SFK inhibitors in the clinical setting requires further investigation. In reviewing the clinical safety data of dasatinib in its current use as a Src inhibitor in a wide variety of solid malignancies, dasatinib appears to be safe and is a promising agent for the treatment of met...Continue Reading

References

Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C A CartwrightW Eckhart
Jan 1, 1993·The Journal of Clinical Investigation·M S TalamontiG E Gallick
Mar 3, 1998·Biochemical and Biophysical Research Communications·M P LutzG Adler
Dec 15, 2000·Oncogene·R B Irby, T J Yeatman
Jul 30, 2003·Cancer Metastasis Reviews·Justin M Summy, Gary E Gallick
Jun 2, 2004·Nature Reviews. Cancer·Timothy J Yeatman
Sep 24, 2004·Cancer Cell·Rumey Ishizawar, Sarah J Parsons
Dec 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maksim V YezhelyevChristiane J Bruns
Oct 6, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Faye M JohnsonNicholas J Donato
Feb 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Holly K DressmanJohnathan M Lancaster
Jun 30, 2007·American Journal of Respiratory and Critical Care Medicine·Anne BergeronPhilippe Rousselot
Aug 28, 2007·Nature Biotechnology·Marcus BantscheffGerard Drewes
Sep 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alfonso Quintás-CardamaJorge Cortes
Jan 10, 2008·Nature Biotechnology·Mazen W KaramanPatrick P Zarrinkar
Jan 29, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael BraveRichard Pazdur
Apr 5, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G Giaccone, P A Zucali
May 20, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R S Finn
Oct 23, 2008·International Journal of Cancer. Journal International Du Cancer·John Araujo, Christopher Logothetis
Jul 4, 2009·Cancer Cell·Xiang H-F ZhangJoan Massagué
Aug 20, 2009·Nature Chemical Biology·Uwe Rix, Giulio Superti-Furga
Sep 30, 2009·Nature Reviews. Clinical Oncology·Lori C KimEric B Haura
Oct 1, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·George D DemetriT R Jeffry Evans
Nov 19, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Evan Y YuCora N Sternberg

❮ Previous
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Citations

May 16, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christine M ChanRebecca E Schweppe
May 16, 2015·Molecular Medicine Reports·Juan XiaoJundong Li
Jul 22, 2011·Journal of Molecular Signaling·Jyoti NautiyalAdhip Pn Majumdar
Feb 26, 2013·The Journal of Pediatrics·Justin Nathaniel BakerAlberto Broniscer
Dec 27, 2011·Cancer Biology & Therapy·Shannon N Westin, Russell R Broaddus
Aug 8, 2018·Journal of Experimental & Clinical Cancer Research : CR·Sai MaMing-Rong Wang
Jan 30, 2020·International Journal of Molecular Sciences·Maria Valeria CataniValeria Gasperi
Apr 3, 2018·Open Medicine·Jun Hyeok LimHong Lyeol Lee
Feb 23, 2020·Oncotarget·Raquel Carvalho MontenegroSusanne Müller
Sep 21, 2013·Therapeutic Drug Monitoring·Debra H JosephsRobert J Flanagan
Sep 10, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Erica L MayerAntonio Llombart-Cussac
Aug 9, 2019·Biochimica Et Biophysica Acta. Molecular Cell Research·Veronica VellaAntonino Belfiore

❮ Previous
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