DAT-SPECT imaging in cases of drug-induced parkinsonism in a specialty movement disorders practice

Parkinsonism & Related Disorders
Jacob YomtoobDanny Bega

Abstract

Compare clinical characteristics and outcomes in cases where DAT-SPECT imaging is used to distinguish Parkinson's disease from Drug-Induced Parkinsonsim. Clinical uncertainty in diagnosing Parkinson's disease is common when patients are on dopamine-blocking medications. DAT-SPECT imaging can improve diagnostic certainty but little data are available on clinical characteristics and outcomes associated with normal and abnormal scan results. Retrospective chart review of patients seen at a movement disorders center between 2011 and 2017 where DAT-SPECT was ordered to distinguish Parkinson's disease from Drug-induced Parkinsonism. Descriptive statistics were calculated for variables of interest and compared by scan result. Chi-squared analyses was carried out for categorical variables and students' t-tests for continuous values. 51 patients met inclusion criteria with 36 normal scans and 15 abnormal scans. Those with greater than 2 cardinal manifestations (tremor, rigidity, akinesia, postural instability) were more likely to have an abnormal scan (63.89% vs 93.33%, p = 0.04). No other clinical characteristics assessed were associated with scan results. Atypical antipsychotics (aripiprazole 39.21%, olanzapine 31.37%) and mood stabil...Continue Reading

Citations

Dec 10, 2019·Clinical Neuropharmacology·Hila YahalomGilad Yahalom
Jul 8, 2019·Lancet Neurology·Stewart A FactorCynthia L Comella
Nov 28, 2019·Deutsches Ärzteblatt International·Ralph BuchertJürgen Gallinat
Oct 5, 2021·Prague Medical Report·Jamir Pitton RissardoÍcaro Durante
Nov 27, 2021·Seminars in Neurology·Andrea Lee, Harini Sarva

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