Data Analysis-Driven Precise Asthmatic Treatment by Targeting Mast Cells.

Endocrine, Metabolic & Immune Disorders Drug Targets
Yupin TanChun-Tao Yang

Abstract

Although the importance of mast cells in asthma has been studied, mast cellsinduced global changes in lungs are largely unknown. Data-driven identification contributes to discovering significant biomarkers or therapeutic targets, which are the basis of effective clinical medications. This study aims to explore the effects of mast cells on gene expression in asthmatic lungs, and to assess the curative effects of inhaled budesonide (BUD). Pulmonary gene expression in KitWsh mice with or without mast cell engraftment was analyzed with R software. Functional enrichment of Gene Ontology and KEGG was carried out through the DAVID online tool. Hub genes were identified with String and Cytoscape software. The array analyses showed that the mast cell engraftment enhanced inflammation/immune response, cytokine/chemokine signal, and monocyte/neutrophil/lymphocyte chemotaxis. Interleukin (IL)-6 was identified to be a significant hub gene with the highest interaction degree. Based on this, the effects of BUD were investigated on the aspects of anti-inflammation. BUD's treatment was found to reduce serum IL-6 content and pulmonary inflammation in ovalbumin-induced asthma rats. The treatment also downregulated beta-tryptase expression both in...Continue Reading

References

Aug 10, 2000·The Journal of Experimental Medicine·C M Williams, S J Galli
Mar 27, 2001·Immunology and Cell Biology·P H Hart
May 28, 2002·The European Respiratory Journal·N G CarrollA L James
Nov 15, 2002·Molecular Immunology·Sean Diehl, Mercedes Rincón
Apr 24, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Cem AkinDean D Metcalfe
Jun 29, 2010·European Journal of Immunology·Akihiro Kimura, Tadamitsu Kishimoto
Nov 10, 2010·Nature Reviews. Immunology·Clare M Lloyd, Edith M Hessel
Nov 25, 2011·Respiratory Medicine·Kawa Amin
Nov 9, 2012·International Journal of Biological Sciences·Mercedes Rincon, Charles G Irvin
Feb 6, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D G Chapman, C G Irvin
Oct 13, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Hong-Qian ChuXue-Tao Wei
Dec 25, 2015·The European Respiratory Journal·Gang WangPeter G Gibson
Jul 7, 2016·Pulmonary Pharmacology & Therapeutics·Girolamo PelaiaRosario Maselli
Jul 1, 2007·Medical Journal, Armed Forces India·S P RaiI M Pandey
Oct 4, 2016·The European Respiratory Journal·Matthew E Poynter, Charles G Irvin
Feb 20, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Chun-Tao YangHui Zhang
May 10, 2017·Pulmonary Pharmacology & Therapeutics·Lennart K A LundbladRobert Schaub
Dec 26, 2017·Clinical Pharmacology : Advances and Applications·Dave SinghThomas Southworth
Apr 5, 2018·Lancet· The Lancet
Jun 15, 2018·The Journal of Allergy and Clinical Immunology·Zala JevnikarUNKNOWN Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes study group
Aug 30, 2018·Allergy and Asthma Proceedings·Umit Murat SahinerBulent Enis Sekerel
Oct 17, 2018·Frontiers in Immunology·Kazuyuki Nakagome, Makoto Nagata
Oct 20, 2018·Molecular and Cellular Endocrinology·Chun-Tao YangJinbao Liu
Mar 31, 2019·The Journal of Allergy and Clinical Immunology·Corinne Cayrol, Jean-Philippe Girard
May 22, 2019·The New England Journal of Medicine·Richard BeasleyUNKNOWN Novel START Study Team
Jul 10, 2019·The American Journal of Clinical Nutrition·Jie V Zhao, C Mary Schooling
Aug 23, 2019·International Journal of Molecular Sciences·Xiner NieBo Li
Nov 30, 2019·Breathe·Michelle A StubbsVanessa M McDonald

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.