Data-driven integration of hippocampal CA1 synaptic physiology in silico.

Hippocampus
András EckerSrikanth Ramaswamy

Abstract

The anatomy and physiology of monosynaptic connections in rodent hippocampal CA1 have been extensively studied in recent decades. Yet, the resulting knowledge remains disparate and difficult to reconcile. Here, we present a data-driven approach to integrate the current state-of-the-art knowledge on the synaptic anatomy and physiology of rodent hippocampal CA1, including axo-dendritic innervation patterns, number of synapses per connection, quantal conductances, neurotransmitter release probability, and short-term plasticity into a single coherent resource. First, we undertook an extensive literature review of paired recordings of hippocampal neurons and compiled experimental data on their synaptic anatomy and physiology. The data collected in this manner is sparse and inhomogeneous due to the diversity of experimental techniques used by different groups, which necessitates the need for an integrative framework to unify these data. To this end, we extended a previously developed workflow for the neocortex to constrain a unifying in silico reconstruction of the synaptic physiology of CA1 connections. Our work identifies gaps in the existing knowledge and provides a complementary resource toward a more complete quantification of s...Continue Reading

References

Jan 15, 1995·The Journal of Physiology·N SprustonB Sakmann
Sep 1, 1995·The European Journal of Neuroscience·E H BuhlP Somogyi
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·M V Tsodyks, H Markram
Aug 15, 1997·Neural Computation·M L Hines, N T Carnevale
Feb 11, 1998·The Journal of Physiology·G StuartB Sakmann
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·H MarkramM Tsodyks
Apr 24, 1999·The European Journal of Neuroscience·A B AliA M Thomson
Jul 25, 2000·Neural Computation·M L Hines, N T Carnevale
Jan 11, 2002·Journal of Neurophysiology·Galit FuhrmannMisha Tsodyks
May 23, 2002·Neural Networks : the Official Journal of the International Neural Network Society·Wolfgang Maass, Henry Markram
Sep 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Marlene BartosPeter Jonas
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Rossella Conti, John Lisman
Jun 28, 1954·The Journal of Physiology·J DEL CASTILLO, B KATZ
Jun 1, 2004·Nature·Frédéric Pouille, Massimo Scanziani
Aug 28, 2004·Trends in Neurosciences·Istvan Mody, Robert A Pearce
Jan 7, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Agota A BiróZoltan Nusser
Jul 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher J PriceMarco Capogna
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason M Christie, Craig E Jahr
Dec 1, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Agota A BiróZoltan Nusser
Oct 20, 2007·The Journal of Physiology·Stephen R Williams, Susan E Atkinson
Jan 25, 2008·Journal of Computational Neuroscience·Michael L HinesFelix Schürmann
Apr 2, 2008·Journal of Computational Neuroscience·Michael L HinesFelix Schürmann

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Citations

Aug 12, 2021·Journal of Neurophysiology·Alexandre Guet-McCreight, Frances K Skinner

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Methods Mentioned

BETA
light microscopy

Software Mentioned

NEURON
GitHub
Python
HippoUnit
Neurolucida
BluePyOpt

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