Data-driven statistical modeling of the emergent behavior of biohybrid microrobots

APL Bioengineering
Eric J LeamanBahareh Behkam

Abstract

Multi-agent biohybrid microrobotic systems, owing to their small size and distributed nature, offer powerful solutions to challenges in biomedicine, bioremediation, and biosensing. Synthetic biology enables programmed emergent behaviors in the biotic component of biohybrid machines, expounding vast potential benefits for building biohybrid swarms with sophisticated control schemes. The design of synthetic genetic circuits tailored toward specific performance characteristics is an iterative process that relies on experimental characterization of spatially homogeneous engineered cell suspensions. However, biohybrid systems often distribute heterogeneously in complex environments, which will alter circuit performance. Thus, there is a critically unmet need for simple predictive models that describe emergent behaviors of biohybrid systems to inform synthetic gene circuit design. Here, we report a data-driven statistical model for computationally efficient recapitulation of the motility dynamics of two types of Escherichia coli bacteria-based biohybrid swarms-NanoBEADS and BacteriaBots. The statistical model was coupled with a computational model of cooperative gene expression, known as quorum sensing (QS). We determined differences...Continue Reading

References

Jan 1, 1988·Cold Spring Harbor Symposia on Quantitative Biology·J Adler, W Shi
Jan 1, 1982·Annual Review of Microbiology·R P Blakemore
Sep 5, 1997·Science·F R BlattnerY Shao
Feb 20, 2003·Journal of Bacteriology·Philip S Stewart
Feb 21, 2004·FEMS Microbiology Reviews·Gladys AlexandreIgor B Zhulin
Mar 3, 2004·Biophysical Journal·Nicholas DarntonHoward C Berg
Dec 2, 2004·Nature Reviews. Molecular Cell Biology·George H Wadhams, Judith P Armitage
Dec 30, 2004·Proceedings of the National Academy of Sciences of the United States of America·Gunnar F KaufmannKim D Janda
Jan 18, 2005·Nature Materials·Jianzhong XiCarlo D Montemagno
Aug 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Douglas B WeibelGeorge M Whitesides
Aug 10, 2006·Journal of Mathematical Biology·Johannes MüllerAnton Hartmann
Sep 8, 2007·Science·Adam W FeinbergKevin Kit Parker
Apr 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Eli Paster, William S Ryu
Jul 26, 2008·Nature Nanotechnology·Demir AkinRashid Bashir
May 2, 2009·Nature·Metin Sitti
Oct 6, 2009·Nature Biotechnology·Howard M SalisChristopher A Voigt
Apr 27, 2010·Annual Review of Biomedical Engineering·Bradley J NelsonJake J Abbott
Apr 5, 2011·Analytical Biochemistry·Ryo IizukaTakashi Funatsu
Jul 9, 2011·Biochimica Et Biophysica Acta·Tania A Baker, Robert T Sauer
Feb 7, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Mahama A TraoréBahareh Behkam
Jun 6, 2012·Sensors·Burkhard A HenseAnton Hartmann
Sep 11, 2012·Biomedical Microdevices·Dongwook KimMetin Sitti
Oct 23, 2012·Trends in Microbiology·Stuart A WestStephen P Diggle
Jul 31, 2013·Biotechnology and Bioengineering·Daechul ParkSukho Park
Sep 3, 2013·Advanced Materials·Veronika MagdanzOliver G Schmidt
Dec 3, 2013·Scientific Reports·Sung Jun ParkSukho Park
Apr 2, 2014·Nature Reviews. Microbiology·D Ewen CameronJames J Collins
Aug 15, 2014·Lab on a Chip·Rika Wright CarlsenMetin Sitti
Mar 5, 2015·Proceedings of the National Academy of Sciences of the United States of America·Charles A SwoffordNeil S Forbes
Jun 16, 2015·Scientific Reports·Jiang ZhuangMetin Sitti
Jun 28, 2016·Scientific Reports·Jiwon HanSukho Park
Jul 21, 2016·Nature·M Omar DinJeff Hasty
Nov 1, 2016·Nature Nanotechnology·Ouajdi FelfoulSylvain Martel
Oct 31, 2016·Advanced Drug Delivery Reviews·Zeinab HosseinidoustMetin Sitti
Aug 23, 2017·Scientific Reports·Jayamary Divya RavichandarCynthia H Collins
Sep 22, 2017·Advanced Science·Jiang ZhuangMetin Sitti

❮ Previous
Next ❯

Citations

Jul 1, 2020·APL Bioengineering·Arianna MenciassiRoger D Kamm

❮ Previous
Next ❯

Methods Mentioned

BETA
motility assays
fluorescence imaging

Software Mentioned

NanoBEADS
BacteriaBots
BacteriaBot
Bacteria

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the Peripheral Nervous System : JPNS
Claudia GrotheStefano Geuna
Chemical Reviews
Stijn F M van DongenJan C M van Hest
Medicine and Health, Rhode Island
Roy K Aaron, Jeffrey R Morgan
© 2021 Meta ULC. All rights reserved