Data-Driven Subgroups in Depression Derived from Directed Functional Connectivity Paths at Rest

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Rebecca B PriceGreg J Siegle

Abstract

Depressed patients show abnormalities in brain connectivity at rest, including hyperconnectivity within the default mode network (DMN). However, there is well-known heterogeneity in the clinical presentation of depression that is overlooked when averaging connectivity data. We used data-driven parsing of neural connectivity to reveal subgroups among 80 depressed patients completing resting state fMRI. Directed functional connectivity paths (eg, region A influences region B) within a depression-relevant network were characterized using Group Iterative Multiple Model Estimation, a method shown to accurately recover the direction and presence of connectivity paths in individual participants. Individuals were clustered using community detection on neural connectivity estimates. Subgroups were compared on network features and on clinical and biological/demographic characteristics that influence depression prognosis. Two subgroups emerged. Subgroup A, containing 71% of the patients, showed a typical pattern of connectivity across DMN nodes, as previously reported in depressed patients on average. Subgroup B exhibited an atypical connectivity profile lacking DMN connectivity, with increased dorsal anterior cingulate-driven connectivit...Continue Reading

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Citations

May 2, 2020·The American Journal of Psychiatry·Timothy Spellman, Conor Liston
Dec 6, 2019·Molecular Psychiatry·Rebecca B Price, Ronald Duman
Aug 12, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amanda M Buch, Conor Liston
Mar 9, 2018·Frontiers in Human Neuroscience·David H V VogelKai Vogeley
Aug 15, 2019·Current Psychiatry Reports·Katharine DunlopConor Liston
May 28, 2020·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Rajpreet ChahalAmanda E Guyer
May 30, 2020·Psychological Medicine·Rajpreet ChahalAmanda E Guyer
Jan 5, 2021·Frontiers in Behavioral Neuroscience·Yin DuJia Liu
Jun 10, 2019·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Logan GrosenickConor Liston
Mar 25, 2021·Clinical Psychological Science : a Journal of the Association for Psychological Science·Rebecca B PriceGreg J Siegle
Nov 17, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Daniel Porta-CasteràsNarcís Cardoner
Sep 3, 2021·Translational Psychiatry·Rebecca B PriceMary Woody

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