DOI: 10.1101/494500Dec 13, 2018Paper

Data from an electronic health informatics pipeline to describe clearance dynamics of Hepatitis B surface antigen (HBsAg) and e-Antigen (HBeAg) in chronic HBV infection

BioRxiv : the Preprint Server for Biology
Louise O DownsPhilippa C Matthews

Abstract

HBsAg and HBeAg have gained traction as biomarkers of control and clearance during chronic hepatitis B virus infection (CHB). Improved understanding of clearance correlates of these proteins could help inform improvements in patient-stratified care and advance insights into underlying mechanisms of disease control, thus underpinning new cure strategies. We collected electronic clinical data via an electronic pipeline supported by the National Institute for Health Research Health Informatics Collaborative (NIHR-HIC), adopting an unbiased approach to generating a robust longitudinal dataset for adults testing HBsAg-positive from a large UK teaching hospital over a six year period (2011-2016 inclusive). From 553 individuals with CHB, longitudinal data were available for 319, representing >107,000 weeks of clinical follow-up. Among these 319 individuals, 13 (4%) cleared HBsAg completely. Among these 13, HBsAg clearance rate was similar in individuals on nucleos(t)ide analogue (NA) therapy (n=4 (31%)), median clearance time 150 weeks) vs those not on NA therapy (n=9 (69%), median clearance time 157 weeks). Those who cleared HBsAg were significantly older, and less likely to be on NA therapy compared to non-clearers (p=0.003 and p=0....Continue Reading

Related Concepts

Academic Medical Centers
Analogs & derivatives
Antigens
Surface Antigens
Biological Markers
Ethnic Group
Patient Care
Hepatitis
Hepatitis B
Hepatitis B e Antigens

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