Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies.

Reproductive Toxicology
Jerrold J HeindelR Thomas Zoeller

Abstract

"Consortium Linking Academic and Regulatory Insights on BPA Toxicity" (CLARITY-BPA) was a comprehensive "industry-standard" Good Laboratory Practice (GLP)-compliant 2-year chronic exposure study of bisphenol A (BPA) toxicity that was supplemented by hypothesis-driven independent investigator-initiated studies. The investigator-initiated studies were focused on integrating disease-associated, molecular, and physiological endpoints previously found by academic scientists into an industry standard guideline-compliant toxicity study. Thus, the goal of this collaboration was to provide a more comprehensive dataset upon which to base safety standards and to determine whether industry-standard tests are as sensitive and predictive as molecular and disease-associated endpoints. The goal of this report is to integrate the findings from the investigator-initiated studies into a comprehensive overview of the observed impacts of BPA across the multiple organs and systems analyzed. For each organ system, we provide the rationale for the study, an overview of methodology, and summarize major findings. We then compare the results of the CLARITY-BPA studies across organ systems with the results of previous peer-reviewed studies from independen...Continue Reading

References

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Citations

Jan 31, 2021·Nature Reviews. Endocrinology·Ana M SotoCarlos Sonnenschein
Feb 3, 2021·Environment International·Véronique SirotMarion Hulin
Jan 23, 2021·Differentiation; Research in Biological Diversity·Gail S Prins
Mar 6, 2021·Environmental Science and Pollution Research International·Nadeem Ghani KhanShama Prasada Kabekkodu
May 12, 2021·Expert Review of Endocrinology & Metabolism·Laura N Vandenberg
May 18, 2021·Current Opinion in Endocrine and Metabolic Research·Alison M Neff, Jodi A Flaws

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Methods Mentioned

BETA
PCA

Software Mentioned

mixOmics R
CLARITY
ImageJ
mixOmics
BPA
BioVis3D

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