Data integrity, reliability and fraud in medical research

European Journal of Internal Medicine
Mark Otto BaerlocherJason Noble

Abstract

Data reliability in original research requires collective trust from the academic community. Standards exist to ensure data integrity, but these safeguards are applied non-uniformly so errors or even fraud may still exist in the literature. To examine the prevalence and consequences of data errors, data reliability safeguards and fraudulent data among medical academics. Corresponding authors of every fourth primary research paper published in the Journal of the American Medical Association (2001-2003), Canadian Medical Association Journal (2001-2003), British Medical Journal (1998-2000), and Lancet (1998-2000) were surveyed electronically. Questions focused on each author's personal experience with data reliability, data errors and data interpretation. Sixty-five percent (127/195) of corresponding authors responded. Ninety-four percent of respondents accepted full responsibility for the integrity of the last manuscript on which they were listed as co-author; however, 21% had discovered incorrect data after publication in previous manuscripts they had co-authored. Fraudulent data was discovered by 4% of respondents in their previous work. Four percent also noted 'smudged' data. Eighty-seven percent of respondents used data relia...Continue Reading

References

Dec 18, 1987·JAMA : the Journal of the American Medical Association·P K Woolf
Jan 15, 1987·Nature·W W Stewart, N Feder
Apr 1, 1999·Academic Medicine : Journal of the Association of American Medical Colleges·D M Parrish
May 11, 2004·BMJ : British Medical Journal·Caroline White
Jan 18, 2005·Mutation Research·Larry D Claxton
Apr 20, 2005·Contemporary Clinical Trials·William GardnerKathryn C Hartwig
Jul 30, 2005·BMJ : British Medical Journal·Jane Smith, Fiona Godlee
Jul 30, 2005·BMJ : British Medical Journal·Caroline White
Jul 30, 2005·BMJ : British Medical Journal·Richard Smith
Apr 28, 2007·International Journal of Surgery·Usman Jaffer, Alan E P Cameron
May 23, 2008·BMC Medical Informatics and Decision Making·Ian ShrierMichel Rossignol
Aug 25, 2009·World Journal of Surgery·Alistair A P Slesser, Yassar A Qureshi

❮ Previous
Next ❯

Citations

Jun 7, 2011·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·W Alan C Mutch
Apr 28, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·José Manuel Lou-BonafontePedro A Martínez-Carpio
Dec 15, 2010·Science Translational Medicine·Robert E Becker, Nigel H Greig
Jul 19, 2013·PloS One·R Grant SteenFerric C Fang
Apr 3, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Robert E Becker, Nigel H Greig
Apr 9, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·A LangenbruchM Augustin
May 2, 2013·The Journal of Manual & Manipulative Therapy·Chad Cook
Jun 15, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Kurt H Albertine
Feb 7, 2019·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Ahmed M Abou-SettaRyan Zarychanski
May 23, 2020·Accountability in Research·Michael D ReisigMarcus E Berzofsky

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved