Data Mining of Small RNA-Seq Suggests an Association Between Prostate Cancer and Altered Abundance of 5' Transfer RNA Halves in Seminal Fluid and Prostatic Tissues

Biomarkers in Cancer
Joseph M DhahbiLuke A Selth

Abstract

Extracellular RNAs are gaining clinical interest as biofluid-based noninvasive markers for diseases, especially cancer. In particular, derivatives of transfer RNA (tRNA) are emerging as a new class of small-noncoding RNAs with high biomarker potential. We and others previously reported alterations in serum levels of specific tRNA halves in disease states including cancer. Here, we explored seminal fluid for tRNA halves as potential markers of prostate cancer. We found that 5' tRNA halves are abundant in seminal fluid and are elevated in prostate cancer relative to noncancer patients. Importantly, most of these tRNA halves are also detectable in prostatic tissues, and a subset were increased in malignant relative to adjacent normal tissue. These findings emphasize the potential of 5' tRNA halves as noninvasive markers for prostate cancer screening and diagnosis and provide leads for future work to elucidate a putative role of the 5' tRNA halves in carcinogenesis.

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Citations

Feb 20, 2020·RNA Biology·Juan Pablo Tosar, Alfonso Cayota
Aug 23, 2020·International Journal of Molecular Sciences·Alina-Andreea ZimtaCiprian Tomuleasa
Oct 1, 2020·Cancers·Joonhyeong ParkSuhwan Chang
Apr 14, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joseph M DhahbiMichal M Masternak
Aug 14, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joseph M DhahbiMichal M Masternak

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Datasets Mentioned

BETA
GSE56686
42
GSE89193

Methods Mentioned

BETA
RNA-Seq

Software Mentioned

Bioconductor package
tRNAscan
Bowtie
UCSC browser
SE
Bedtools
EdgeR
Ensembl

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