Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity.

Data in Brief
María N BarrachinaÁngel García

Abstract

This data article is associated with the manuscript "GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: elucidating potential anti-atherothrombotic targets in obesity" [1]. The study refers to a combination of different approaches in order to identify platelet-derived biomarkers in obesity. A total of 34 obese patients and their lean-matched controls were included in the study. We carried out a proteomic and functional (aggregation assays) analysis to find alterations in platelet-derived signalling pathways. After that, biochemical and mechanistic (flow cytometry assays) approaches were done in order to confirm a hyperactivation of the GPVI-related signalling pathway.

Citations

Nov 6, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·María N BarrachinaÁngel García

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Methods Mentioned

BETA
electrophoresis
Flow Cytometry
immunoprecipitation

Software Mentioned

Data Analysis
ImageJ
Ingenuity Pathways Analysis
Mascot
BioTools
GraphPad Prism
SamesSpots
Ingenuity Pathways Analysis ( IPA ) STRING
SPSS Statistics
STRING

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