Data quality and relevance in ecotoxicity: The undocumented influences of model assumptions and modifying factors on aquatic toxicity dose metrics

Regulatory Toxicology and Pharmacology : RTP
L S McCarty

Abstract

A model-based approach using hypothetical organic chemicals examines how aquatic toxicity test results are influenced by toxicity modifying factors such as hydrophobicity, exposure duration, body size, lipid content, mode of toxic action (via Critical Body Residue differences), and metabolic degradation. Differences of up to one to three orders of magnitude were identified for modeled LC50s. Dominance of CBR by low log Kow chemicals can cause further influences. Such differences cause significant changes in the relationship between exposure- and organism-based doses and create substantial difficulties for both interpretation of test results and extrapolation to other laboratory or field exposure conditions. The resulting variability is not readily evident in toxicity testing as insufficient data are collected to validate fundamental assumptions. Consequently, results obtained with standard aquatic toxicity test protocols do not yield consistent, comparable measures of relative toxicity and are inappropriate for quantitative toxicology and risk applications. The substantial uncertainties in testing results created by such undocumented variability must also be given serious consideration in data quality and relevance assessments....Continue Reading

References

Oct 30, 2004·Environmental Toxicology and Chemistry·Jon A Arnot, Frank A P C Gobas
Apr 1, 2006·Environmental Science & Technology·Jong-Hyeon Lee, Peter F Landrum
May 17, 2006·Regulatory Toxicology and Pharmacology : RTP·L S McCarty, C J Borgert
Jun 5, 2008·Environmental Toxicology and Chemistry·Jon A ArnotMark Bonnell
Dec 9, 2009·The Science of the Total Environment·Jan BaasBas Kooijman
Sep 24, 2010·Journal of Environmental Monitoring : JEM·Roman Ashauer, Beate I Escher
Feb 11, 2012·Environmental Science & Technology·Roman AshauerBeate I Escher
May 15, 2012·Regulatory Toxicology and Pharmacology : RTP·L S McCarty
May 31, 2013·Environmental Toxicology and Chemistry·L S McCartyD Mackay
Sep 24, 2013·Regulatory Toxicology and Pharmacology : RTP·L S McCarty
Apr 25, 2014·Environmental Science & Technology·Anna-Maija NymanRoman Ashauer
Jun 4, 2014·Environmental Toxicology and Chemistry·Donald MackayJon A Arnot

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Citations

Mar 29, 2016·Integrated Environmental Assessment and Management·Lynn S McCarty, Christopher J Borgert
Mar 1, 2017·Environmental Science. Processes & Impacts·Mark T D Cronin
Jan 4, 2020·Archives of Environmental Contamination and Toxicology·Djohan DjohanD W Connell
Sep 29, 2020·Environmental Toxicology and Chemistry·L S McCartyL D Burgoon

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