Data sets for the qualification of volumetric CT as a quantitative imaging biomarker in lung cancer

Optics Express
Andrew J BucklerR S Avila

Abstract

The drug development industry is faced with increasing costs and decreasing success rates. New ways to understand biology as well as the increasing interest in personalized treatments for smaller patient segments requires new capabilities for the rapid assessment of treatment responses. Deployment of qualified imaging biomarkers lags apparent technology capabilities. The lack of consensus methods and qualification evidence needed for large-scale multi-center trials, as well as the standardization that allows them, are widely acknowledged to be the limiting factors. The current fragmentation in imaging vendor offerings, coupled with the independent activities of individual biopharmaceutical companies and their contract research organizations (CROs), may stand in the way of the greater opportunity were these efforts to be drawn together. A preliminary report, "Volumetric CT: a potential biomarker of response," of the Quantitative Imaging Biomarkers Alliance (QIBA) activity was presented at the Medical Imaging Continuum: Path Forward for Advancing the Uses of Medical Imaging in the Development of New Biopharmaceutical Products meeting of the Extended Pharmaceutical Research and Manufacturers of America (PhRMA) Imaging Group sponso...Continue Reading

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Citations

Feb 5, 2014·Abdominal Imaging·Meghan G LubnerPerry J Pickhardt
Dec 3, 2014·Academic Radiology·Andrew B RosenkrantzLeon Lenchik
Apr 23, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·James L MulshineCarolyn R Aldigé
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Jul 6, 2014·Journal of Digital Imaging·Yoganand BalagurunathanRobert J Gillies
Feb 28, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrea G RockallJames D Brenton

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