Daurisoline suppressed early afterdepolarizations and inhibited L-type calcium current

The American Journal of Chinese Medicine
Qiang-Ni LiuFan-Dian Zeng

Abstract

Our previous studies have shown that daurisoline (DS) exerted antiarrhythmic effects on various experimental arrhythmias. In this study, the effects of DS on early afterdepolarizations (EADs) and its possible mechanisms have been investigated. Cardiac hypertrophy was induced in rabbits by coarctating the abdominal aorta. The effects of DS on action potential duration (APD) and the incidences of EADs were studied in hypertrophied papillary muscles of rabbits in the conditions of low external K(+) concentration ([K(+)]o) and dofetilide (dof) by using standard microelectrode technique. The whole-cell patch clamp was used to record the L-type calcium current (I(Ca-L)) in isolated left ventricular cells of rabbits. The results showed that in hypertrophied papillary muscles of rabbits with low [K(+)]o ([K(+)]o = 2.7 mM), 1 microM dof prolonged APD(50) and APD(90) markedly and the incidence of EADs was 66.7% (4/6, p < 0.01); when 15 microM DS was applied, the incidence of EADs was 0% (0/4, p < 0.01) and the prolonged APD was shortened (p < 0.01). In a single myocyte, DS could also inhibit EADs induced by dof, low [K(+)]o and low external Mg(2+) concentration ([Mg(2+)]o) ([Mg(2+)](o) = 0.5 mM). DS could decrease the triangulation. In a...Continue Reading

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Citations

Mar 8, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bo ZhaoLian-Jun Guo
Nov 8, 2014·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·S MadronichX Y Tang
Aug 1, 2020·Frontiers in Pharmacology·Dmitry I OsmakovSergey A Kozlov
Aug 7, 2019·Biomolecules·Dmitry I OsmakovSergey A Kozlov
Sep 15, 2012·Journal of Natural Products·Qiangni LiuXiaoyan Yang

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