Dawn- and dusk-phased circadian transcription rhythms coordinate anabolic and catabolic functions in Neurospora

BMC Biology
Cigdem SancarMichael Brunner

Abstract

Circadian clocks control rhythmic expression of a large number of genes in coordination with the 24 hour day-night cycle. The mechanisms generating circadian rhythms, their amplitude and circadian phase are dependent on a transcriptional network of immense complexity. Moreover, the contribution of post-transcriptional mechanisms in generating rhythms in RNA abundance is not known. Here, we analyzed the clock-controlled transcriptome of Neurospora crassa together with temporal profiles of elongating RNA polymerase II. Our data indicate that transcription contributes to the rhythmic expression of the vast majority of clock-controlled genes (ccgs) in Neurospora. The ccgs accumulate in two main clusters with peak transcription and expression levels either at dawn or dusk. Dawn-phased genes are predominantly involved in catabolic and dusk-phased genes in anabolic processes, indicating a clock-controlled temporal separation of the physiology of Neurospora. Genes whose expression is strongly dependent on the core circadian activator WCC fall mainly into the dawn-phased cluster while rhythmic genes regulated by the glucose-dependent repressor CSP1 fall predominantly into the dusk-phased cluster. Surprisingly, the number of rhythmic tra...Continue Reading

References

Jun 15, 1995·Genes & Development·Y LiuT Kondo
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·D Bell-PedersenJ C Dunlap
Feb 22, 2001·Annual Review of Physiology·J J Loros, J C Dunlap
Apr 23, 2002·Nature·Kai-Florian StorchCharles J Weitz
May 23, 2002·Cell·Satchidananda PandaJohn B Hogenesch
Apr 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Allan C FroehlichJay C Dunlap
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Alejandro CorreaDeborah Bell-Pedersen
Feb 24, 2006·Current Opinion in Cell Biology·Domenico MaioranoMarcel Méchali
Nov 17, 2006·Journal of Biological Rhythms·Michael W VitaliniDeborah Bell-Pedersen
Apr 25, 2007·FEBS Letters·Thierry ClaudelFrédéric Gachon
Aug 31, 2007·Biostatistics·Mark D Robinson, Gordon K Smyth
Nov 29, 2007·Cellular and Molecular Life Sciences : CMLS·R E HalbeisenA P Gerber
Mar 4, 2008·Molecular Microbiology·Michael Brunner, Krisztina Káldi
Mar 18, 2008·FEBS Letters·Tina GlisovicGideon Dreyfuss
Mar 6, 2009·Genome Biology·Ben LangmeadSteven L Salzberg
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Andrew ClarkJeremy Saklatvala
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Chaoguang TianN Louise Glass
Feb 13, 2010·Annual Review of Physiology·Charna DibnerUrs Albrecht
Oct 29, 2010·Genome Biology·Simon Anders, Wolfgang Huber
Nov 5, 2010·Journal of Cell Science·Marina Maria Bellet, Paolo Sassone-Corsi
Dec 4, 2010·Science·Joseph Bass, Joseph S Takahashi
Jan 8, 2011·Applied Microbiology and Biotechnology·Bernhard Seiboth, Benjamin Metz
Feb 18, 2011·Plant Signaling & Behavior·Alfredo SanchezSeth J Davis
Apr 2, 2011·FEBS Letters·Tobias Schafmeier, Axel C R Diernfellner
Jun 29, 2011·FEMS Microbiology Reviews·Christopher L BakerJay C Dunlap
Apr 21, 2012·Briefings in Bioinformatics·Helga ThorvaldsdóttirJill P Mesirov
May 25, 2012·Trends in Genetics : TIG·Sylvain EgloffShona Murphy
Aug 25, 2012·Current Biology : CB·Dawn H Nagel, Steve A Kay
Oct 3, 2012·Genes & Development·Jing-Ping Hsin, James L Manley

❮ Previous
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Citations

Dec 19, 2015·BioMed Research International·Shujing Li, Luoying Zhang
Oct 27, 2015·Fungal Genetics and Biology : FG & B·Jennifer M HurleyJay C Dunlap
Aug 9, 2016·Trends in Biochemical Sciences·Jennifer M HurleyJay C Dunlap
Aug 11, 2016·Proceedings of the National Academy of Sciences of the United States of America·Stephen Z CasterDeborah Bell-Pedersen
Dec 21, 2017·BMC Genomics·Ibrahim Avi CemelMichael Brunner
Dec 23, 2015·Nature Communications·Zongzhao ZhaiBruno Lemaitre
May 3, 2019·Proceedings of the National Academy of Sciences of the United States of America·Mokryun BaekChristian I Hong
Aug 8, 2015·G3 : Genes - Genomes - Genetics·Jennifer H HurleyJay C Dunlap
Jun 16, 2017·Biotechnology for Biofuels·Tiziano BenocciRonald P de Vries
Dec 5, 2018·Communications Biology·Hang-Hyun JoPan-Jun Kim
Jun 4, 2020·Journal of the Royal Society, Interface·Md Mamunur Rashid, Hiroyuki Kurata
Jul 28, 2020·Journal of Neurochemistry·Shashank Bangalore Srikanta, Nicolas Cermakian
Sep 24, 2020·Journal of Biological Rhythms·Benjamin A Unruh, Shihoko Kojima
May 2, 2018·Fungal biology and biotechnology·Monika Schmoll
Nov 26, 2018·Communications Biology·Hang-Hyun JoPan-Jun Kim
May 2, 2020·Proceedings of the National Academy of Sciences of the United States of America·Shanta KarkiDeborah Bell-Pedersen
Dec 15, 2018·The European Journal of Neuroscience·Helen C Causton
Apr 2, 2021·G3 : Genes - Genomes - Genetics·Felipe Muñoz-GuzmánLuis F Larrondo
May 21, 2017·Microbiology Spectrum·Jay C Dunlap, Jennifer J Loros

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Datasets Mentioned

BETA
PRJNA248256

Methods Mentioned

BETA
RNA-seq
ChIP-seq
PCR
immunoprecipitation
ChIP-PCRs
ChIP

Software Mentioned

ARSER
MIPS FunCat
R
FunCat
locfit
Bowtie
MASS package of

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