Dawn of lipid nanoparticles in lymph node targeting: Potential in cancer immunotherapy.

Advanced Drug Delivery Reviews
Takashi Nakamura, Hideyoshi Harashima

Abstract

It is generally known that the lymph nodes (LNs) are important tissues in cancer immunotherapy. Therefore, delivering immune functional compounds to LNs is a useful strategy for enhancing cancer immunotherapy. Lipid-based nanocarriers have been widely used as delivery systems that target LNs, but lipid nanoparticle (LNP) technology has recently attracted increased interest. High levels of nucleic acids can be efficiently loaded in LNPs, they can be used to actively deliver nucleic acids into the cytoplasm, and they can be produced on an industrial scale. The use of microfluidic devices has been particularly valuable for producing small-sized LNPs, thus paving the way for successful LN targeting. In the review, we focus on the potential of LNP technology for targeting LNs.

Citations

Feb 24, 2021·International Journal of Biological Macromolecules·Adelijiang WusimanDeyun Wang
May 8, 2021·Experimental Biology and Medicine·Noah Trac, Eun Ji Chung
May 25, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Apratim JashSyed S H Rizvi
Jun 3, 2021·Pharmaceutics·Saed Abbasi, Satoshi Uchida
Aug 8, 2021·Advanced Drug Delivery Reviews·Yingyue DingQuanyin Hu
Sep 1, 2021·Pharmaceutical Research·Sifei HanNatalie Trevaskis

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