Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP

Biochemical and Biophysical Research Communications
Muhnho LaCheol O Joe

Abstract

Daxx-mediated transcriptional repression was modulated by a speckled POZ domain protein SPOP which was first identified as an autoantigen from the serum of a scleroderma patient. This is the first report on the biochemical and functional interactions between Daxx and SPOP. The COOH-terminal region of Daxx interacts with the NH2-terminal region of SPOP. SPOP reversed the transcriptional repression mediated by Daxx which binds with ETS1 transcription factor to repress ETS1-responsive gene expression. Mutagenesis study suggests that the ability of SPOP to self-associate as well as its ability to bind with Daxx was important for the modulation of Daxx-mediated transcriptional repression.

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Citations

Dec 19, 2008·Journal of the Royal Society, Interface·Joana P GonçalvesAndré X C N Valente
Jul 15, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yuping HuangXianghuo He
Jan 13, 2006·Trends in Cell Biology·Paolo Salomoni, Amel F Khelifi
Jul 25, 2014·Drug Discovery Today·Ram-Shankar Mani
Oct 13, 2006·American Journal of Physiology. Renal Physiology·Arup ChakrabortyDavid Sheikh-Hamad
Jan 26, 2008·The Journal of Biological Chemistry·Matthew W BunceRichard A Anderson

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