Day-night differences in estimated rates of 5-hydroxytryptamine turnover in the rat pineal gland

Experimental Brain Research
T S KingR J Reiter

Abstract

Rates of 5-hydroxytryptamine synthesis in various brain tissues can be estimated from the linear increase in 5-hydroxytryptophan levels following inhibition of 5-hydroxytryptophan decarboxylation with RO4-4602 or NSD-1015. In addition, NSD-1015 can prevent 5-hydroxytryptamine oxidative-deamination via monoamine oxidase inhibition, leading to linear decreases in a major metabolite of this amine, 5-hydroxyindole acetic acid. In the rat pineal gland we demonstrated similar increases in 5-hydroxytryptophan levels after nocturnal or diurnal injection of RO4-4602 (100 mg X kg-1) or NSD-1015 (200 mg X kg-1). Similar decreases in 5-hydroxyindole acetic acid were also observed after nocturnal or diurnal injection of NSD-1015 or pargyline (an inhibitor of monoamine oxidase) (75 mg X kg-1). 5-Hydroxytryptamine levels increased after nocturnal pargyline injection but remained constant after diurnal pargyline administration. 5-Hydroxytryptamine levels exhibited little change following nocturnal injection of NSD-1015 but decreased linearly after diurnal injection of NSD-1015. We suggest that (1) rat pineal 5-hydroxytryptamine synthesis is increased nocturnally, (2) metabolic utilization, primarily by oxidative-deamination, of 5-hydroxytrypta...Continue Reading

Citations

Oct 1, 1991·Cellular and Molecular Neurobiology·K B Thomas, P M Iuvone
Jan 1, 1989·Journal of Neural Transmission. General Section·B BensonC A Leadem
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·P B FoleyA Foldes
Jan 1, 1990·Progress in Neurobiology·W Wesemann, N Weiner
Sep 17, 1998·Brain Research Bulletin·I Kostoglou-Athanassiou, M L Forsling
May 15, 1989·Experientia·K BlumM C Trachtenberg
Jan 1, 1986·Journal of Pineal Research·R F WalkerM E Rush
Jan 1, 1987·Journal of Pineal Research·P B Foley, K D Cairncross

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