Day-night pattern of autonomic nervous system modulation in patients with heart failure with and without sleep apnea

International Journal of Cardiology
Linda M UenoGeraldo Lorenzi-Filho

Abstract

Among patients with congestive heart failure (CHF) both obstructive and central sleep apnea (SA) are associated with increased sympathetic activity. However, the day-night pattern of cardiac autonomic nervous system modulation in CHF patients with and without sleep apnea is unknown. Twenty-five CHF patients underwent polysomnography with simultaneous beat-to-beat blood pressure (Portapres), respiration and electrocardiogram monitoring. Patients were divided according to the presence (SA, n=17) and absence of SA (NoSA, n=8). Power spectral analyses of heart rate variability (HRV) and spontaneous baroreflex sensitivity (BRS) were determined in periods with stable breathing while awake at 6 am, 10 am, 10 pm, as well as during stage 2 sleep. In addition, muscle sympathetic nerve activity (MSNA) was evaluated at 10 am. RR variance, low-frequency (LF), high-frequency (HF) powers of HRV, and BRS were significantly lower in patients with SA compared with NoSA in all periods. HF power, a marker of vagal activity, increased during sleep in patients with NoSA but in contrast did not change across the 24-hour period in patients with SA. MSNA was significantly higher in patients with SA compared with NoSA. RR variance, LF and HF powers corr...Continue Reading

References

Apr 8, 1999·American Journal of Respiratory and Critical Care Medicine·G Lorenzi-FilhoT D Bradley
Apr 8, 1999·American Journal of Respiratory and Critical Care Medicine·D BrooksE A Phillipson
Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·D D SinT D Bradley
Mar 29, 2001·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·C F Notarius, J S Floras
Jul 19, 2001·Annals of the New York Academy of Sciences·G ParatiG Mancia
Nov 29, 2001·Journal of Hypertension·A G LoganT D Bradley
Mar 11, 2003·American Journal of Respiratory and Critical Care Medicine·Richard S T LeungT Douglas Bradley
Sep 6, 2003·Journal of the American College of Cardiology·Fabiana RovedaCarlos Eduardo Negrão
May 20, 2005·American Journal of Respiratory and Critical Care Medicine·Luciano F DragerGeraldo Lorenzi-Filho
Jun 18, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L M UenoT Moritani
Oct 26, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L M UenoC E Negrão
Apr 17, 2007·Journal of the American College of Cardiology·Hanqiao WangT Douglas Bradley
Apr 17, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Andrea Di VannaCarlos E Negrão
Jun 26, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R S SilvaG Lorenzi-Filho
Dec 3, 2008·International Journal of Cardiology·Andrew J S Coats
Dec 27, 2008·Progress in Cardiovascular Diseases·Richard S T Leung
Jan 10, 2009·Journal of the American College of Cardiology·Maria Teresa La RovereOreste Febo

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Citations

Nov 17, 2012·BMC Cardiovascular Disorders·Paolo MelilloLeandro Pecchia
Dec 2, 2011·Sleep·Barbara RiegelJoseph Libonati
Jun 27, 2014·PloS One·Akiomi YoshihisaYasuchika Takeishi
May 20, 2015·International Journal of Cardiology·Songyun WangHong Jiang
Mar 19, 2013·European Journal of Heart Failure·Takashi KoyamaHiroshi Ito
Jan 8, 2011·Journal of the American College of Cardiology·Takatoshi Kasai, T Douglas Bradley
Mar 18, 2021·Environmental Health : a Global Access Science Source·Luyi LiXinbiao Guo
Nov 11, 2011·Current Opinion in Anaesthesiology
Jan 10, 2012·Current Opinion in Anaesthesiology

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