Daylight methyl-aminolevulinate photodynamic therapy versus ingenol mebutate for the treatment of actinic keratoses: an intraindividual comparative analysis

Dermatologic Therapy
Giovanni GenoveseSanto R Mercuri

Abstract

Daylight-photodynamic therapy (D-PDT) and ingenol mebutate (IM) are novel therapies directed to actinic keratoses (AK). The purpose of our study was to compare effectiveness, tolerability, cosmetic outcome and patient preference of D-PDT versus IM in the treatment of grade I and II AK. Twenty-seven patients with AK on the face or scalp were enrolled. Each patient received, in a 25 cm(2) target area, D-PDT on right side and IM on left side. Overall 323 AK were treated. Both target areas achieved complete response in 40.47% of the cases and average AK clearance rate was similar for D-PDT and IM (p=0.74). In D-PDT areas mean grade II AK clearance rate was lower compared with that of grade I AK (p=0.015). In IM areas grade I and II AK average clearance rates were similar (p=0.28). At week 1 and month 1, mean local skin responses (LSR) score were higher in areas treated with IM. IM areas showed more severe pain and cosmetic sequelae. D-PDT had similar effectiveness to IM, even if IM demonstrated higher grade II AK clearance rate. Tolerability profile was superior for D-PDT in terms of LSR and pain. D-PDT was more cosmetically acceptable. Patients preferred D-PDT to IM in most cases.

References

Jan 4, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·S R WiegellL R Braathen
Mar 16, 2012·The New England Journal of Medicine·Mark LebwohlBrian Berman
May 4, 2013·American Journal of Clinical Dermatology·Aman Samrao, Clay J Cockerell
May 8, 2013·The British Journal of Dermatology·R N WernerA Nast
Mar 13, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·B DrénoUNKNOWN AKTeam™

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Citations

Jan 18, 2017·The British Journal of Dermatology·D de BerkerB R Hughes
Apr 14, 2017·Journal of Cutaneous Medicine and Surgery·Piergiacomo Calzavara-PintonRolf-Markus Szeimies
Jun 26, 2017·Photodiagnosis and Photodynamic Therapy·Xiang WenMichael R Hamblin
Jan 4, 2018·Photomedicine and Laser Surgery·Santo Raffaele MercuriSteven Paul Nisticò
May 17, 2018·Dermatologic Therapy·Santo Raffaele MercuriSteven Paul Nisticò
Jul 13, 2018·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Piergiacomo Calzavara-PintonNeda T Tanova
Apr 24, 2018·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Rolf-Markus Szeimïes
Apr 24, 2018·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Carlota Gutiérrez García-RodrigoMaria Concetta Fargnoli
Sep 6, 2018·The British Journal of Dermatology·S H IbbotsonL S Exton
Jul 11, 2020·Dermatologic Therapy·Elvira MoscarellaGiuseppe Argenziano
May 13, 2018·American Journal of Clinical Dermatology·Colin A Morton, Lasse R Braathen
Apr 5, 2019·Oncology Letters·Mircea TampaSimona-Roxana Georgescu

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