Daylight Photodynamic Therapy for Actinic Keratoses

American Journal of Clinical Dermatology
Colin A Morton, Lasse R Braathen

Abstract

Topical photodynamic therapy (PDT) using daylight is effective in the treatment of actinic keratoses (AKs), offering the potential for treatment of large fields such as full face and balding scalp, but with minimal therapy-associated pain. Comparison with conventional PDT indicates similar efficacy for thin and moderate-thickness AKs, but with significantly less discomfort/pain, driving a patient preference for daylight-mediated PDT (DL-PDT) compared with conventional PDT using high-intensity office/hospital-based light sources. Treatment protocol involves the application of a photosensitizing agent without occlusion and subsequent exposure to ambient daylight within 30 min, with patients exposed to daylight for 1.5-2.0 h. Pivotal randomized controlled trials in Europe and Australia have confirmed the efficacy of methyl aminolevulinic acid (MAL) DL-PDT in comparison with conventional MAL-PDT for mild and moderate-thickness lesions on the face and scalp. Initial clearance rates of 70-89% are reported. DL-PDT using a nanoemulsion aminolevulinic acid (ALA) has recently been shown to be at least as effective as MAL DL-PDT in treating mild and moderate-thickness AKs. DL-PDT may offer a better-tolerated method for treating patients w...Continue Reading

References

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Citations

Feb 6, 2020·Journal of Bioinformatics and Computational Biology·Huiqing WangChunlin Dong
Jun 27, 2020·British Journal of Cancer·Huayun Shi, Peter J Sadler
Jul 24, 2020·Nature Reviews. Clinical Oncology·Xingshu LiXiaoyuan Chen
Nov 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nicholas J Collier, Lesley E Rhodes
May 1, 2021·International Journal of Molecular Sciences·Mariana C S VallejoMaria Graça P M S Neves
Nov 11, 2019·Advanced Drug Delivery Reviews·Jason K CullenGlen M Boyle
Dec 11, 2021·British Journal of Nursing : BJN·Hazel McPhillipsBruce Harper-McDonald

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