Daylight photodynamic therapy versus cryosurgery for the treatment and prophylaxis of actinic keratoses of the face - protocol of a multicenter, prospective, randomized, controlled, two-armed study

BMC Dermatology
E KohlSigrid Karrer

Abstract

Photodynamic therapy with daylight (DL-PDT) is efficacious in treating actinic keratosis (AK), but the efficacy of field-directed, repetitive DL-PDT for the treatment and prophylaxis of AK in photodamaged facial skin has not yet been investigated. In this multicenter, prospective, randomized, controlled, two-armed, observer-blinded trial, patients with a minimum of 5 mild-to-moderate AK lesions on photodamaged facial skin are randomly allocated to two treatment groups: DL-PDT with methyl aminolevulinate (MAL) and cryosurgery. In the DL-PDT group (experimental group), 5 treatments of the entire face are conducted over the course of 18 months. After preparation of the lesion and within 30 min after MAL application, patients expose themselves to daylight for 2 h. In the control group, lesion-directed cryosurgery is conducted at the first visit and, in the case of uncleared or new AK lesions, also at visits 2 to 5. The efficacy of the treatment is evaluated at visits 2 to 6 by documenting all existing and new AK lesions in the face. Cosmetic results and improvement of photoaging parameters are evaluated by means of a modified Dover scale. Primary outcome parameter is the cumulative number of AK lesions observed between visits 2 and...Continue Reading

Associated Clinical Trials

Apr 13, 2016·Professor Dr. Sigrid Karrer

References

Apr 1, 1997·Journal of the American Academy of Dermatology·J P CallenR L Moy
May 20, 1998·Journal of the American Optometric Association·J Ruskiewicz
Sep 11, 2004·International Journal of Dermatology·Keng-Ee ThaiPeter Foley
Dec 8, 2004·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·C C Zouboulis, H Röhrs
Oct 19, 2005·Archives of Dermatology·Jeffrey S DoverKenneth A Arndt
May 10, 2007·The British Journal of Dermatology·J Röwert-HuberE Stockfleth
Oct 22, 2008·Archives of Dermatology·Jeffrey S OrringerJohn J Voorhees
Nov 21, 2009·Journal of the American Academy of Dermatology·Min Young ParkYou Chan Kim
Dec 17, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Maria Cláudia Almeida IssaMônica Manela-Azulay
Jan 26, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·I SchaeferT Kornek
Mar 21, 2013·The Journal of Investigative Dermatology·Sophie C FlohilTamar Nijsten
Apr 16, 2013·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·E Kohl, S Karrer
Dec 9, 2014·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Thomas L DiepgenPeter Elsner
May 29, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K Togsverd-BoM Haedersdal
Aug 26, 2015·Skin Pharmacology and Physiology·Jean KrutmannMarkus Szeimies
Mar 5, 2016·The New England Journal of Medicine·Andrew C ChenDiona L Damian
Mar 5, 2016·The New England Journal of Medicine·Francesco DragoAurora Parodi
Aug 9, 2016·The British Journal of Dermatology·J A SiegelM A Weinstock

❮ Previous
Next ❯

Citations

Mar 15, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·M Fernández-GuarinoP Jaén Olasolo
Apr 11, 2018·Dermatologic Therapy·C Pindado-OrtegaB Pérez-García
May 13, 2018·American Journal of Clinical Dermatology·Colin A Morton, Lasse R Braathen
Dec 3, 2020·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·W G Philipp-DormstonK-M Thoms

❮ Previous
Next ❯

Methods Mentioned

BETA
pregnancy test

Clinical Trials Mentioned

NCT02736760

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.