Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers.

Annals of Neurology
Sam GandyMichelle E Ehrlich

Abstract

Recent evidence suggests that high molecular weight soluble oligomeric Abeta (oAbeta) assemblies (also known as Abeta-derived diffusible ligands, or ADDLs) may represent a primary neurotoxic basis for cognitive failure in Alzheimer disease (AD). To date, most in vivo studies of oAbeta/ADDLs have involved injection of assemblies purified from the cerebrospinal fluid of human subjects with AD or from the conditioned media of Abeta-secreting cells into experimental animals. We sought to study the bioactivities of endogenously formed oAbeta/ADDLs generated in situ from the physiological processing of human amyloid precursor protein (APP) and presenitin1 (PS1) transgenes. We produced and histologically characterized single transgenic mice overexpressing APP(E693Q) or APP(E693Q) X PS1DeltaE9 bigenic mice. APP(E693Q) mice were studied in the Morris water maze (MWM) task at 6 and 12 months of age. Following the second MWM evaluation, mice were sacrificed, and brains were assayed for Abetatotal, Abeta40, Abeta42, and oAbeta/ADDLs by enzyme-linked immunosorbent assay (ELISA) and were also histologically examined. Based on results from the oAbeta/ADDL ELISA, we assigned individual APP(E693Q) mice to either an undetectable oAbeta/ADDLs gro...Continue Reading

References

Mar 1, 1996·Neurobiology of Aging·K AndräM Staufenbiel
Dec 1, 1995·Journal of the Neurological Sciences·A H KoeppenJ A McEvoy
Nov 3, 1998·Journal of Neurochemistry·G K GourasS Gandy
Dec 21, 2004·Nature Neuroscience·James P ClearyKaren H Ashe
May 3, 2005·Behavioural Brain Research·Lynn A HydeGuy A Higgins
May 3, 2005·The Journal of Clinical Investigation·Sam Gandy
Oct 6, 2005·The Journal of Cell Biology·W Haung YuRalph A Nixon
Oct 26, 2005·Neurobiology of Disease·Claudia G AlmeidaGunnar K Gouras
Mar 17, 2006·Nature·Sylvain LesnéKaren H Ashe
Mar 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·J Steven JacobsenFloyd E Bloom
Mar 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ganesh M ShankarBernardo L Sabatini
Feb 3, 2009·Frontiers of Neurology and Neuroscience·Panteleimon GiannakopoulosConstantin Bouras
Feb 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Robert M KoffieTara L Spires-Jones
May 1, 2009·American Journal of Alzheimer's Disease and Other Dementias·Toshiya Fukui, Eiyai Lee
May 26, 2009·Behavioural Brain Research·Jan LaczóJakub Hort
Jul 3, 2009·ASN Neuro·Iliya LefterovRadosveta Koldamova
Aug 7, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Davide TampelliniGunnar K Gouras
Nov 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Xiaoyan HuJin-Moo Lee
Jan 27, 2010·The Mount Sinai Journal of Medicine, New York·Alex L Lublin, Sam Gandy

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Citations

May 4, 2011·Cellular and Molecular Neurobiology·Kyle C WilcoxWilliam L Klein
Mar 23, 2011·Molecular Neurobiology·Daniel W WessonDonald A Wilson
Oct 15, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francesco MoriDiego Centonze
Jan 19, 2013·Annual Review of Medicine·Sam Gandy, Steven T DeKosky
Dec 6, 2012·Translational Neurodegeneration·Lin ZhengAlexei Terman
Jan 25, 2013·Journal of Cell Science·Matthew E SewardGeorge S Bloom
Oct 28, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Davide TampelliniGunnar K Gouras
Oct 29, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Davide TampelliniGunnar K Gouras
Jul 5, 2012·The Journal of Chemical Physics·Matthew S ChurchAlan E van Giessen
Mar 1, 2012·Neuroscience and Biobehavioral Reviews·R LalondeC Strazielle
May 24, 2016·EBioMedicine·Urmi SenguptaRakez Kayed
May 27, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anand Kant DasSudipta Maiti
May 25, 2016·Neurology. Neuroimmunology and Neuroinflammation·Elysse M KnightJohn W Steele
Jul 19, 2014·Neurobiology of Aging·Gustavo Basurto-IslasKhalid Iqbal
Jul 1, 2018·The Journal of Biological Chemistry·Alessandro EmendatoAnnalisa Pastore
Apr 8, 2018·The Journal of Experimental Medicine·Angie C A ChiangJoanna L Jankowsky
Mar 27, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Janine KutzscheDieter Willbold
Jan 30, 2020·Frontiers in Immunology·Yan-Mei HuangHai-Lu Zhao
Jun 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dieter Willbold, Janine Kutzsche
Jan 29, 2019·World Journal of Gastroenterology : WJG·Jung Hwan YoonWon Sang Park
Aug 28, 2020·Sensors·Celia Toyos-RodríguezAlfredo de la Escosura-Muñiz
May 15, 2021·The Journal of Experimental Medicine·Sam Gandy, Michelle E Ehrlich
May 30, 2019·Analytical Chemistry·Jihyun YoonJoon Won Park

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