Daytime cardiac repolarization in patients with obstructive sleep apnea

Sleep & Breathing = Schlaf & Atmung
Abu ShamsuzzamanVirend K Somers

Abstract

Obstructive sleep apnea (OSA) has been implicated in complications of cardiovascular disease, including arrhythmias and sudden cardiac death (SCD). Prolonged QT interval is associated with arrhythmias and SCD in patients with cardiovascular disease and apparently healthy humans. Apneic episodes during sleep in OSA patients are associated with QT prolongation due to increased vagal activity, but it is not understood whether chronic QT prolongation persists during normoxic daytime wakefulness. To determine whether daytime QT intervals in OSA patients are prolonged compared to control subjects, we recruited 97 (76 male, 21 female) newly diagnosed patients with OSA [apnea-hypopnea index (AHI) ≥5 events/h] and 168 (100 male, 68 female) healthy volunteers (AHI <5 events/h) and measured daytime resting QT and RR intervals from the electrocardiograms to determine QT prolongation corrected for heart rate (QTc). All subjects with OSA were older and heavier, with increased heart rate, significantly increased AHI and arousal index, and reduced oxygen saturation (SpO2) during sleep, and spent less time in sleep with >90 % SpO2 compared to respective controls. QTc in patients with OSA (410 ± 3.3 for male and 433 ± 5.6 for female) was signifi...Continue Reading

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Citations

Sep 1, 2015·Sleep & Breathing = Schlaf & Atmung·Steiner StephanMeyer Christian
Mar 14, 2016·Sleep & Breathing = Schlaf & Atmung·Younghoon KwonUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Group
Jan 1, 2019·Circulation Reports·Jacob N BlackwellYounghoon Kwon
Jul 24, 2020·Sleep Medicine Research·Younghoon KwonChi-Hang Lee
Mar 17, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Benedikt LinzThomas Jespersen
Mar 30, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Jessica FitzpatrickGhada Bourjeily

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