Daytime diurnal curve comparison between the fixed combinations of latanoprost 0.005%/timolol maleate 0.5% and dorzolamide 2%/timolol maleate 0.5%

Eye
Anastasios G P KonstasWilliam C Stewart

Abstract

The diurnal efficacy and safety of the fixed combinations of latanoprost/timolol given once daily vs dorzolamide/timolol given twice daily in primary open-angle glaucoma or ocular hypertensive patients. A double-masked, two-centre, crossover comparison. In 33 patients, the mean diurnal IOP (0800-2000, measured every 2 h) for latanoprost/timolol fixed combination was 17.3+/-2.2 mmHg and for dorzolamide/timolol, the fixed combination was 17.0+/-2.0 mmHg (P = 0.36). Additionally, there was no statistical difference for individual time points following a Bonferroni correction. A bitter taste was found more frequently with the dorzolamide/timolol fixed combination (n = 6) than the latanoprost/timolol fixed combination (n = 0) (P = 0.040), while the latanoprost/timolol fixed combination demonstrated more conjunctival hyperaemia (n = 9) than the dorzolamide/timolol fixed combination (n = 2) (P = 0.045). One patient was discontinued early from the dorzolamide/timolol fixed combination due to elevated IOP. This study suggests that the daytime diurnal IOP is not statistically different between the dorzolamide/timolol fixed combination and latanoprost/timolol fixed combination in primary open-angle glaucoma and ocular hypertensive patients.

References

Feb 1, 1997·Archives of Ophthalmology·A G KonstasW C Stewart
May 8, 1998·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·T K MundorfW C Stewart
Oct 28, 1999·Current Opinion in Ophthalmology·W C Stewart
May 31, 2002·American Journal of Ophthalmology·Anastasios G P KonstasWilliam C Stewart
Jul 6, 2002·Archives of Ophthalmology·Eve J HigginbothamUNKNOWN Fixed Combination Investigative Group

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Citations

Feb 11, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Mumin Hakan ErenSenol Sabanci
Aug 30, 2008·Drugs & Aging·Carroll A B WebersJan S A G Schouten
Dec 17, 2008·Survey of Ophthalmology·Rania TabetAnastasios G P Konstas
May 18, 2005·Journal of Clinical Pharmacy and Therapeutics·M P VenturaM N Burnier
Feb 26, 2016·Advances in Therapy·Anastasios G P KonstasStefano Miglior
Jun 29, 2013·Expert Opinion on Pharmacotherapy·Anastasios Gp KonstasMurat Irkec
Oct 28, 2020·Advances in Therapy·Anastasios G KonstasL Jay Katz

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