Abstract
The diurnal efficacy and safety of the fixed combinations of latanoprost/timolol given once daily vs dorzolamide/timolol given twice daily in primary open-angle glaucoma or ocular hypertensive patients. A double-masked, two-centre, crossover comparison. In 33 patients, the mean diurnal IOP (0800-2000, measured every 2 h) for latanoprost/timolol fixed combination was 17.3+/-2.2 mmHg and for dorzolamide/timolol, the fixed combination was 17.0+/-2.0 mmHg (P = 0.36). Additionally, there was no statistical difference for individual time points following a Bonferroni correction. A bitter taste was found more frequently with the dorzolamide/timolol fixed combination (n = 6) than the latanoprost/timolol fixed combination (n = 0) (P = 0.040), while the latanoprost/timolol fixed combination demonstrated more conjunctival hyperaemia (n = 9) than the dorzolamide/timolol fixed combination (n = 2) (P = 0.045). One patient was discontinued early from the dorzolamide/timolol fixed combination due to elevated IOP. This study suggests that the daytime diurnal IOP is not statistically different between the dorzolamide/timolol fixed combination and latanoprost/timolol fixed combination in primary open-angle glaucoma and ocular hypertensive patients.
References
Oct 1, 1987·Acta Ophthalmologica·G R Duff
Jan 1, 1996·Ophthalmology·P Watson, J Stjernschantz
Jan 1, 1996·Ophthalmology·C B Camras
Feb 1, 1997·Archives of Ophthalmology·A G KonstasW C Stewart
Dec 1, 1995·Ophthalmology·A Alm, J Stjernschantz
Aug 1, 1997·Archives of Ophthalmology·A G KonstasW C Stewart
May 8, 1998·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·T K MundorfW C Stewart
Jan 30, 1999·The British Journal of Ophthalmology·J HutzelmannE Vargas
Oct 28, 1999·Current Opinion in Ophthalmology·W C Stewart
Apr 25, 2001·Eye·A G KonstasW C Stewart
May 5, 2001·American Journal of Ophthalmology·W C StewartK E Latham
May 31, 2002·American Journal of Ophthalmology·Anastasios G P KonstasWilliam C Stewart
Jul 6, 2002·Archives of Ophthalmology·Eve J HigginbothamUNKNOWN Fixed Combination Investigative Group
Oct 23, 2002·Acta Ophthalmologica Scandinavica. Supplement·N OrzalesiP Fogagnolo
Jun 5, 2003·Acta Ophthalmologica Scandinavica·William C StewartElizabeth D Sharpe
Jul 18, 2003·Ophthalmology·Anastasios G P KonstasWilliam C Stewart
Citations
Dec 19, 2009·Eye·S MigliorUNKNOWN Xalacom/Cosopt European Study Group
Mar 18, 2006·Eye·I F Hepsen, E Ozkaya
Feb 11, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Mumin Hakan ErenSenol Sabanci
Dec 6, 2008·Trials·Oghenowede EyawoEdward J Mills
Dec 19, 2013·PloS One·Miao HeWenyong Huang
Jan 1, 2010·Drug, Healthcare and Patient Safety·Parul Ichhpujani, L Jay Katz
Aug 30, 2008·Drugs & Aging·Carroll A B WebersJan S A G Schouten
Jun 13, 2012·Drugs·Florent AptelJean-Paul Romanet
Jun 17, 2011·Journal of Glaucoma·Michelle OrmeJane Loftus
Dec 14, 2006·Ophthalmic Research·Cengaver Tamer, Hüseyin Oksüz
Dec 18, 2009·Current Medical Research and Opinion·M OrmeJ Loftus
Feb 23, 2008·Current Eye Research·Barbara CvenkelWilliam C Stewart
Dec 17, 2008·Survey of Ophthalmology·Rania TabetAnastasios G P Konstas
May 18, 2005·Journal of Clinical Pharmacy and Therapeutics·M P VenturaM N Burnier
Feb 26, 2016·Advances in Therapy·Anastasios G P KonstasStefano Miglior
Jun 29, 2013·Expert Opinion on Pharmacotherapy·Anastasios Gp KonstasMurat Irkec
Mar 28, 2008·The Annals of Pharmacotherapy·Mark R LeskNatacha R Bastien
Feb 28, 2020·PloS One·Yi XingShaohua Huang
Oct 28, 2020·Advances in Therapy·Anastasios G KonstasL Jay Katz