Daytime rhythm and treatment-related fluctuations of serum phosphorus concentration in dialysis patients

American Journal of Nephrology
Liesbeth ViaeneP Evenepoel

Abstract

Serum phosphorus concentrations reflect a dynamic balance between generation, exchanges, and removal. Time-averaged phosphorus concentrations (TAC(phos)) reflect the overall exposure better than single time-point concentrations, especially in dialysis patients treated with an intermittent modality. The present study aimed to determine the daytime rhythm of phosphorus in dialysis patients and to compare the TAC(phos) in continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis (HD) patients. Serum concentrations of urea nitrogen, creatinine and phosphorus were determined at regular intervals in 10 healthy volunteers (HV), 8 CAPD patients and 10 HD patients. In HV and CAPD patients, blood was sampled at 08:30 (fasting), 09:30, 10:30, 12:30, 16:30, and 08:30 h the next day. In HD patients, blood was sampled before and after the midweek dialysis session and rebound was assessed at regular time-points post-dialysis. TAC(phos) were determined according to the trapezoidal rule. Serum phosphorus levels show a daytime rhythm in CAPD patients, similar to what is observed in HV, with a nadir around 10:30 h and a rise in the afternoon. The magnitude of this daytime fluctuation is limited as compared to the treatment-related fluctua...Continue Reading

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Citations

Feb 12, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Grégoire WuerznerOlivier Bonny
Feb 26, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pieter EvenepoelDirk Kuypers
Oct 6, 2020·Hemodialysis International·Ketili Alice DarioRosa M A Moysés
Jan 24, 2021·Journal of Nephrology·Kullaya TakkavatakarnPaweena Susantitaphong
Dec 30, 2021·Hemodialysis International·Elizabeth R StremkeSharon M Moe

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