DBA/2J mouse model for experimental glaucoma: pitfalls and problems

Clinical & Experimental Ophthalmology
Anita J TurnerStuart L Graham

Abstract

The DBA/2J mouse has been described as a model for congenital experimental glaucoma. It develops anterior segment anomalies with synechiae and pigment dispersion leading to raised intraocular pressure and glaucomatous damage. However, there are serious practical considerations when using this model in longitudinal studies. We followed 118 mice from 12-48 weeks of age in a pharmaceutical trial. Here we report on the findings in control animals (n = 37). Intraocular pressure was measured weekly, electrophysiology and optical coherence tomography every 6 weeks. A subset also had invasive intraocular pressure measurements performed prior to euthanasia. Although intraocular pressure eventually rose by 9 months in most animals, tonometry was complicated by corneal calcification in the majority of animals rendering intraocular pressure measurement unreliable. Invasive intraocular pressure did not correlate with non-invasive measures. Loss of scotopic threshold response and thinning of inner retinal layers on optical coherence tomography was observed over time, suggesting glaucomatous damage, but this occurred in some animals without raised intraocular pressure. Poor pupil dilation significantly affected electrophysiology, optical cohe...Continue Reading

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Citations

Dec 23, 2017·Clinical & Experimental Ophthalmology·Bang V Bui
Jun 15, 2018·Clinical & Experimental Ophthalmology·Chelsea GuymerRobert J Casson
Nov 20, 2018·Investigative Ophthalmology & Visual Science·Ben MeadStanislav Tomarev
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May 22, 2018·Journal of Ophthalmology·Adrian A Lahola-Chomiak, Michael A Walter
Jan 27, 2021·International Journal of Molecular Sciences·Michal FiedorowiczMario Damiano Toro
Feb 3, 2021·ACS Applied Materials & Interfaces·Sven SchnichelsAndreas Herrmann
Dec 19, 2020·Frontiers in Neurology·Sara TirendiAlberto Izzotti
Jul 30, 2020·Progress in Retinal and Eye Research·Sven SchnichelsAlexa Klettner
Mar 18, 2021·Scientific Reports·Martin WeberBaris Bingol
Jul 7, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Sven SchnichelsAndreas Herrmann
Mar 25, 2021·Current Eye Research·Gavin W RoddyMichael P Fautsch

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