Mar 14, 2014

dBigH1, a second histone H1 in Drosophila, and the consequences for histone fold nomenclature

Epigenetics : Official Journal of the DNA Methylation Society
Rodrigo González-Romero, Juan Ausió


Recently, Pérez-Montero and colleagues (Developmental cell, 26: 578-590, 2013) described the occurrence of a new histone H1 variant (dBigH1) in Drosophila. The presence of unusual acidic amino acid patches at the N-terminal end of dBigH1 is in contrast to the arginine patches that exist at the N- and C-terminal domains of other histone H1-related proteins found in the sperm of some organisms. This departure from the strictly lysine-rich composition of the somatic histone H1 raises a question about the true definition of its protein members. Their minimal essential requirements appear to be the presence of a lysine- and alanine-rich, intrinsically disordered C-terminal domain, with a highly helicogenic potential upon binding to the linker DNA regions of chromatin. In metazoans, specific targeting of these regions is further achieved by a linker histone fold domain (LHFD), distinctively different from the characteristic core histone fold domain (CHFD) of the nucleosome core histones.

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Mentioned in this Paper

Carboxy-Terminal Amino Acid
Post-Translational Protein Processing
Drosophila melanogaster Proteins
Tertiary Protein Structure
Linker DNA
Histone Fold
Nucleosome Core Particle
Histone H1

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