DBS sampling in imatinib therapeutic drug monitoring: from method development to clinical application

Bioanalysis
Marina Venzon AntunesRafael Linden

Abstract

Imatinib (IM) is widely used in treatment of chronic myeloid leukemia with target trough plasma concentrations above 1000 ng ml(-1). DBS can increase access to IM therapeutic drug monitoring. IM was measured in the range 50-4000 ng ml(-1) by UHPLC-MS/MS using one 6 mm DBS in a fully validated method. IM was stable at DBS maintained at 40°C for 36 days. Plasma and DBS concentrations were highly correlated (r > 0.96). The use of a IM concentration target of 765 ng ml(-1) in DBS identified 93% of patients with plasma concentration below 1000 ng ml(-1). IM can be measured in DBS using UHPLC-MS/MS with results comparable to those obtained in blood plasma.

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Citations

May 18, 2016·Clinical Biochemistry·Marina Venzon AntunesRafael Linden
Apr 19, 2016·Expert Opinion on Drug Metabolism & Toxicology·Suzanne L ParkerJason A Roberts
Jul 28, 2016·Journal of Pharmaceutical and Biomedical Analysis·Johannes J M RoodRolf W Sparidans
Jun 24, 2017·The Journal of Pharmacy and Pharmacology·Christel C L M BoonsEleonora L Swart
Dec 10, 2017·European Journal of Clinical Pharmacology·A E C A B WillemsenN P van Erp
Dec 5, 2018·Biomedical Chromatography : BMC·Suresh P SulochanaRamesh Mullangi
Jun 9, 2019·European Journal of Clinical Pharmacology·Stefanie L GroenlandNeeltje Steeghs
May 21, 2020·British Journal of Clinical Pharmacology·Bradley D MenzStephanie E Reuter
Feb 8, 2019·European Journal of Clinical Pharmacology·Christel C L M BoonsN Harry Hendrikse

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Software Mentioned

Xcalibur
SPSS
Medcalc

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