Feb 5, 2015

dbSUPER: a database of super-enhancers in mouse and human genome

BioRxiv : the Preprint Server for Biology
Aziz Khan, Xuegong Zhang

Abstract

Super-enhancers are the clusters of transcriptional enhancers that can drive cell-type-specific gene expression and also crucial in cell identity. Many disease-associated sequence variations are enriched in super-enhancer regions of disease-relevant cell types. Thus, super-enhancers can be used as potential biomarkers for disease diagnosis and therapeutics. Current studies have identified super-enhancers in more than 100 cell types and demonstrated their functional importance. However, no centralized resource to integrate all these findings is available yet. We developed dbSUPER (http://bioinfo.au.tsinghua.edu.cn/dbsuper/), the first integrated and interactive database of super-enhancers, with the primary goal of providing a resource for assistance in further studies related to transcriptional control of cell identity and disease. dbSUPER provides a responsive and user-friendly web interface to facilitate efficient and comprehensive search and browsing. The data can be easily sent to Galaxy instances, GREAT and Cistrome web servers for downstream analysis, and can be visualized in UCSC genome browser while custom tracks added automatically. The data can be downloaded and exported in variety of formats. Further, dbSUPER lists ge...Continue Reading

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Mentioned in this Paper

Biological Markers
Study
Transcriptional Regulation
Genome
Genes
Genetic Analysis
Transcription, Genetic
Genetic Research
Maintenance of Meristem Identity
Gene Expression

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