DC-derived TSLP promotes Th2 polarization in LPS-primed allergic airway inflammation.

European Journal of Immunology
Yanlu ZhangBaohua Zhou

Abstract

Thymic stromal lymphopoietin (TSLP) plays important roles in the pathogenesis of allergic diseases. Whether and how TSLP is involved in the initial priming of T helper type-2 (Th2) differentiation against harmless antigen remains unclear. Using an intranasal sensitization protocol with OVA and LPS, we showed that TSLP signaling is required for low-dose LPS-induced Th2 inflammation, but not for high-dose LPS-induced Th1 immunity. We further demonstrated that low-dose LPS-activated bone marrow-derived dendritic cells expressed relatively high Tslp but low Il12a, and were able to prime naïve DO11.10 T cells to differentiate into Th2 cells in a TSLP-dependent manner. After transfer into wild-type recipient mice, the low-dose LPS-activated OVA-loaded dendritic cells (DCs) induced airway eosinophilia, but primed neutrophil-dominated airway inflammation when TSLP-deficient DCs were used. These studies demonstrate that TSLP released by DCs in response to a low concentration of LPS plays a role in priming Th2 differentiation and thus may serve as a polarizing third signal, in addition to antigen/MHC class II and co-stimulatory factors, from antigen-presenting DCs to direct effector T-cell differentiation.

References

Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R A SederM Plaut
Jul 1, 1995·American Journal of Respiratory Cell and Molecular Biology·A J CoyleG P Anderson
Apr 1, 1994·The Journal of Experimental Medicine·T Yoshimoto, W E Paul
Dec 10, 1999·Nature·D B Corry, F Kheradmand
Aug 15, 2000·European Journal of Immunology·C RuedlM Kopf
Jul 30, 2002·Nature Immunology·Dale T UmetsuRosemarie H DeKruyff
Dec 18, 2002·The Journal of Experimental Medicine·Stephanie C EisenbarthKim Bottomly
Nov 25, 2003·Current Opinion in Immunology·Stephanie C EisenbarthKim Bottomly
Dec 4, 2003·Nature Reviews. Immunology·Bart N Lambrecht, Hamida Hammad
Aug 18, 2004·The Journal of Experimental Medicine·Booki MinWilliam E Paul
Jan 15, 2005·The Journal of Clinical Investigation·Damani A PiggottKim Bottomly
Mar 23, 2005·The Journal of Experimental Medicine·Leonie S van RijtBart N Lambrecht
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sun YingChris Corrigan
Sep 6, 2005·Nature Immunology·Baohua ZhouSteven F Ziegler
Sep 21, 2005·The Journal of Experimental Medicine·Amin Al-ShamiWarren J Leonard
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mei LiPierre Chambon
Nov 9, 2005·The Journal of Experimental Medicine·Tomoki ItoYong-Jun Liu
Dec 2, 2005·The European Respiratory Journal·S N GeorasV Casolaro
Jan 25, 2006·The Journal of Experimental Medicine·Yong-Jun Liu
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hai-Chon Lee, Steven F Ziegler
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Miyuki Omori, Steven Ziegler
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sofia I BogiatziVassili Soumelis
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoon-Keun KimZhou Zhu
Feb 27, 2008·Nature Immunology·Caroline L SokolRuslan Medzhitov
Aug 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Rui HeRaif S Geha
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Baohua ZhouSteven F Ziegler
Mar 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna M TanH Kim Bottomly
Mar 17, 2010·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Khoa D NguyenKari C Nadeau
Oct 1, 2010·Trends in Immunology·Jeremy P McAleer, Anthony T Vella
Jan 19, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Liying LeiBaohua Zhou
May 10, 2011·Nature Immunology·Brandon M SullivanRichard M Locksley
Jun 22, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohit KashyapWarren J Leonard

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Citations

Nov 15, 2013·Respirology : Official Journal of the Asian Pacific Society of Respirology·Zhi-Hua ChenHua-Hao Shen
Oct 30, 2013·European Journal of Immunology·Bart N Lambrecht, Hamida Hammad
Apr 17, 2015·Cellular Immunology·Guoqing YingShuqing Chen
Dec 3, 2014·The Journal of Allergy and Clinical Immunology·Qun WangBaohua Zhou
Jan 24, 2015·Current Allergy and Asthma Reports·Catherine HammondJoshua L Kennedy
Sep 10, 2014·Pharmacology & Therapeutics·Hamish PhilpottSimon G Royce
Jun 12, 2016·The Journal of Allergy and Clinical Immunology·Naruhito IwasakiTomohiro Yoshimoto
Jul 21, 2016·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Hongyi TanXiaoli Su
Oct 30, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F M CarlierC Pilette
Jan 14, 2017·Scientific Reports·Maria J RodriguezCristobalina Mayorga
Jul 6, 2014·Allergy, Asthma & Immunology Research·Hae-Jin Lee, Seung-Hun Lee
Mar 21, 2019·Allergy·Kazuhiko MaedaShizuo Akira
Mar 7, 2020·Allergy, Asthma & Immunology Research·Sang Chul ParkSung Jae Shin
May 30, 2019·Frontiers in Immunology·Matthew J ElderJane C Goodall
Apr 25, 2020·International Journal of Molecular Sciences·Gabsik YangJoo Young Lee
Oct 4, 2017·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Zhuang-Gui ChenTian-Tuo Zhang
Apr 2, 2019·The Journal of Clinical Investigation·Florence RoanSteven F Ziegler
Mar 22, 2016·Experimental and Therapeutic Medicine·Jian-Guo LiPi-Xin Ran

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