D&C nos. 10 and 11: chemical composition analysis and delayed contact hypersensitivity testing in the guinea pig

Contact Dermatitis
Y SatoT Mitsui

Abstract

D&C Yellow no. 11 was found to consist predominantly of quinophthalone together with other minor components, though not 6'-methylquinophthalone. Quinophthalone was found to be a strong sensitizer in guinea pigs by means of a modified testing technique, and its threshold concentration for induction and challenge was 10 ppm. Purified D&C Yellow no. 10, which was found to consist of 6 derivatives of sodium sulfonated quinophthalone, did not sensitize or elicit a cross-reaction in quinophthalone-sensitized guinea pigs even at a challenge concentration of 5%. Commercial D&C Yellow no. 10 contained 0.95-170 ppm of quinophthalone, and it is suggested that skin sensitization by D&C Yellow no. 10 is caused by contaminating quinophthalone.

References

Jan 1, 1975·Contact Dermatitis·C D Calnan
Jun 1, 1976·Contact Dermatitis·C D Calnan
May 1, 1982·Contact Dermatitis·S A LamsonS J De Salva
May 1, 1981·Journal of the American Academy of Dermatology·W P Jordan
Sep 1, 1981·Contact Dermatitis·C D Calnan

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Citations

Jan 1, 1996·Clinics in Dermatology·A Dooms-Goossens, I Blockeel
Jan 1, 1988·Journal of Toxicology and Environmental Health·S M el DareerD L Hill
Apr 29, 2009·Contact Dermatitis·Denis Sasseville, Valérie Joncas
Mar 5, 2004·Contact Dermatitis·Jere D Guin
Oct 1, 1984·Contact Dermatitis·S KitaA M Kligman
Mar 1, 1989·Contact Dermatitis·H KomamuraM Iyoda
Feb 1, 1987·Contact Dermatitis·K E AndersenT Menné
Aug 13, 1999·Contact Dermatitis·M Kimura, A Kawada
Dec 6, 2020·Contact Dermatitis·María E Gatica-OrtegaCristina Pérez-Hortet

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