DC-SIGN and L-SIGN can act as attachment receptors for alphaviruses and distinguish between mosquito cell- and mammalian cell-derived viruses

Journal of Virology
William B KlimstraKate D Ryman

Abstract

C-type lectins such as DC-SIGN and L-SIGN, which bind mannose-enriched carbohydrate modifications of host and pathogen proteins, have been shown to bind glycoproteins of several viruses and facilitate either cis or trans infection. DC-SIGN and L-SIGN are expressed in several early targets of arbovirus infection, including dendritic cells (DCs) and cells of the reticuloendothelial system. In the present study, we show that DC-SIGN and L-SIGN can function as attachment receptors for Sindbis (SB) virus, an arbovirus of the Alphavirus genus. Human monocytic THP-1 cells stably transfected with DC-SIGN or L-SIGN were permissive for SB virus replication, while untransfected controls were essentially nonpermissive. The majority of control THP-1 cells were permissive when attachment and entry steps were eliminated through electroporation of virus transcripts. Infectivity for the DC-SIGN/L-SIGN-expressing cells was largely blocked by yeast mannan, EDTA, or a DC-SIGN/L-SIGN-specific monoclonal antibody. Infection of primary human DCs by SB virus was also dependent upon SIGN expression by similar criteria. Furthermore, production of virus particles in either C6/36 mosquito cells or CHO mammalian cells under conditions that limited complex ...Continue Reading

References

Jul 1, 1977·Somatic Cell Genetics·P Stanley, L Siminovitch
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B M CurtisA J Watson
Aug 1, 1980·International Journal of Cancer. Journal International Du Cancer·S TsuchiyaK Tada
Jan 1, 1994·Methods in Enzymology·G P Kaushal, A D Elbein
Aug 8, 1998·Journal of Virology·A P Byrnes, D E Griffin
Jan 7, 2000·Journal of Virology·G H MacDonald, R E Johnston
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E J SoilleuxJ Trowsdale
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·S PöhlmannR W Doms
Dec 18, 2001·The Journal of Pathology·E J SoilleuxN Coleman
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anneke EngeringYvette van Kooyk
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Miguel RellosoAngel L Corbí
Mar 26, 2002·Nature Reviews. Immunology·Carl G FigdorGosse J Adema
Mar 14, 2003·Journal of Virology·Stefan PöhlmannJane A McKeating
Apr 12, 2003·The Journal of Experimental Medicine·Boonrat TassaneetrithepMary A Marovich

❮ Previous
Next ❯

Citations

May 7, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ui-Soon KhooC L Steve Lin
Jan 8, 2013·Cell Biochemistry and Biophysics·Lan-Juan ZhaoZhong-Tian Qi
Oct 25, 2013·Journal of Medicinal Chemistry·Janice A SindacScott D Larsen
Feb 26, 2008·Nature Biotechnology·Lili YangPin Wang
Apr 20, 2005·Nature Genetics·Anavaj SakuntabhaiCécile Julier
Sep 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Christina L GardnerWilliam B Klimstra
Dec 26, 2006·Vector Borne and Zoonotic Diseases·Konstantin TsetsarkinDana L Vanlandingham
Jun 1, 1979·The Journal of Pharmacy and Pharmacology·A Seiden, D Lichtenberg
Nov 22, 2005·Infection and Immunity·Rhoel R Dinglasan, Marcelo Jacobs-Lorena
Mar 15, 2013·Journal of Virology·Kristin M LongMark T Heise
Nov 19, 2010·Journal of Virology·Sabrina R HuntDennis T Brown
Jan 18, 2006·Journal of Virology·Carl W DavisTheodore C Pierson
Apr 25, 2012·Journal of Tropical Medicine·Marijke M F Alen, Dominique Schols
Jan 1, 2009·Journal of Innate Immunity·Kristin M Rogers, Mark Heise
Jun 17, 2011·Virology Journal·Joseph P KononchikDennis T Brown
May 1, 2012·PLoS Neglected Tropical Diseases·Charles K NfonHana M Weingartl
Jan 25, 2008·PLoS Pathogens·Jennifer L KonopkaRobert E Johnston
Feb 9, 2012·Advances in Virology·Jason Yat-Sing LeungJustin Jang Hann Chu
Jan 15, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Semih U TareenScott H Robbins
Sep 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Emmanuel G CormierTatjana Dragic
Mar 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael AnishchenkoScott C Weaver
Oct 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Scott A JeffersKathryn V Holmes
Dec 12, 2012·Current Opinion in Virology·Peng ZhongWalther Mothes
Mar 24, 2012·Current Opinion in Virology·Marija Backovic, Felix A Rey
Jan 29, 2014·Journal of Proteome Research·Max CrispinThomas A Bowden
Mar 12, 2005·Cellular Microbiology·Alessandra CambiCarl G Figdor
May 14, 2016·Nature Microbiology·Xiaojing PangGong Cheng
Oct 8, 2008·Immunological Reviews·Kate D Ryman, William B Klimstra
Nov 26, 2010·The Journal of Gene Medicine·Xia Zhang, Monica J Roth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.