DC-SIGN facilitates fusion of dendritic cells with human T-cell leukemia virus type 1-infected cells.

Journal of Virology
Pierre-Emmanuel CeccaldiSimona Ozden

Abstract

Interactions between the oncogenic retrovirus human T-cell leukemia virus type 1 (HTLV-1) and dendritic cells (DCs) are poorly characterized. We show here that monocyte-derived DCs form syncytia and are infected upon coculture with HTLV-1-infected lymphocytes. We examined the role of DC-specific ICAM-3-grabbing nonintegrin (DC-SIGN), a C-type lectin expressed in DCs, in HTLV-1-induced syncytium formation. DC-SIGN is known to bind with high affinity to various viral envelope glycoproteins, including human immunodeficiency virus (HIV) and hepatitis C virus, as well as to the cellular receptors ICAM-2 and ICAM-3. After cocultivating DCs and HTLV-1-infected cells, we found that anti-DC-SIGN monoclonal antibodies (MAbs) were able to decrease the number and size of HTLV-1-induced syncytia. Moreover, expression of the lectin in epithelial-cell lines dramatically enhanced the ability to fuse with HTLV-1-positive cells. Interestingly, in contrast to the envelope (Env) glycoproteins of HIV and other viruses, that of HTLV-1 does not bind directly to DC-SIGN. The facilitating role of the lectin in HTLV-1 syncytium formation is mediated by its interaction with ICAM-2 and ICAM-3, as demonstrated by use of MAbs directed against these adhesion...Continue Reading

References

Nov 1, 1990·Journal of Virology·J H RichardsonA G Dalgleish
May 3, 1986·Lancet·M OsameM Tara
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M YoshidaY Hinuma
Jan 1, 1993·Advances in Experimental Medicine and Biology·S C KnightS Patterson
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·K J JefferyC R Bangham
Mar 23, 2001·Nature Immunology·T B GeijtenbeekY van Kooyk
Jun 7, 2002·Journal of Virology·Carmen P AlvarezRafael Delgado
Aug 15, 2002·Journal of Virological Methods·Christelle Royer-LeveauSimona Ozden
Sep 18, 2002·Immunological Reviews·Yvette van Kooyk, Teunis B H Geijtenbeek
Feb 18, 2003·Science·Tadahiko IgakuraCharles R M Bangham
Mar 1, 2003·The Journal of Biological Chemistry·Pierre-Yves LozachRalf Altmeyer
Apr 15, 2003·Journal of Virology·Cinzia NobileOlivier Schwartz
Jun 6, 2003·Current Opinion in Immunology·Alain Trautmann, Salvatore Valitutti
Oct 25, 2003·Blood·Arnaud MorisOlivier Schwartz
Nov 19, 2003·Cell·Nicolas ManelJean-Luc Battini
Dec 4, 2003·The Journal of General Virology·Charles R M Bangham
Jan 22, 2004·The Journal of Experimental Medicine·Clare JollyQuentin J Sattentau
May 8, 2004·Seminars in Immunology·Marie LarssonNina Bhardwaj
Aug 7, 2004·Traffic·Clare Jolly, Quentin J Sattentau
Dec 21, 2004·The Journal of Infectious Diseases·Misao SatomiHidemi Takahashi

❮ Previous
Next ❯

Citations

May 29, 2008·Antimicrobial Agents and Chemotherapy·Emanuela BalestrieriBeatrice Macchi
Nov 15, 2008·PLoS Pathogens·Philippe V AfonsoIgnacio A Romero
Aug 4, 2009·PLoS Pathogens·Giulia Freer, Donatella Matteucci
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Veronique LepoutreZafar K Khan
Oct 14, 2011·Viruses·Michael D LairmorePatrick L Green
Jan 26, 2010·World Journal of Biological Chemistry·Noula Shembade, Edward W Harhaj
Mar 24, 2012·Current Opinion in Virology·Marija Backovic, Felix A Rey
Sep 22, 2010·Cellular Microbiology·Theodros Solomon Tsegaye, Stefan Pöhlmann
Mar 23, 2012·Immunological Reviews·Jonathan K Chan, Warner C Greene
May 5, 2009·PLoS Pathogens·Kristopher J KoudelkaMarianne Manchester
Jul 1, 2010·Viruses·Mohamed Nejmeddine, Charles R M Bangham
Mar 24, 2016·Viruses·Christine Gross, Andrea K Thoma-Kress
Dec 25, 2019·Retrovirology·Brenda RocamondeHélène Dutartre
Jul 22, 2014·Experimental Dermatology·Takatoshi Shimauchi, Vincent Piguet
Jul 15, 2015·Médecine sciences : M/S·Gerges RizkallahHélène Dutartre
Mar 30, 2018·Frontiers in Microbiology·Amandine PasquierRenaud Mahieux
Sep 1, 2018·The Journal of Infectious Diseases·Michelle L PleetFatah Kashanchi
Nov 24, 2020·Frontiers in Immunology·Wilfried PoschDoris Wilflingseder

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.