DCC protein as a predictor of distant metastases after curative surgery for rectal cancer

Diseases of the Colon and Rectum
M A ReymondF Köckerling

Abstract

The aim of this study was to determine the value of DCC (deleted in colorectal cancer) protein for predicting metachronous distant metastases after curative surgery for rectal cancer. The DCC protein--for which a gene has been located on chromosome 18q--has recently been reported to have a prognostic value in colorectal cancer. This finding might have implications for treatment of International Union Against Cancer Stage II rectal carcinoma, in which distant metastases will develop in 14 percent of patients despite optimal surgery. Paraffin-embedded tissues from 85 patients who developed distant metastases, but no local recurrence, after curative surgery for rectal cancer were matched with 85 samples from patients who remained disease-free. Matching criteria were tumor stage, age, gender, and date of surgery. Expression of DCC protein was assessed using immunohistochemistry. End points of follow-up were recurrence of disease and death. Mean follow-up was 9.6 years. No patient received either local or systemic adjuvant therapy. The DCC protein was found to be expressed in 64.9 percent of tumor samples. Nonexpression of DCC protein had an negative influence on survival (P = 0.03). For all tumor stages together, sensitivity of the...Continue Reading

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Citations

Nov 23, 2000·Diseases of the Colon and Rectum·S D Wexner, N A Rotholtz
Mar 11, 2006·International Journal of Colorectal Disease·Khaled M MadboulyVictor W Fazio
Aug 12, 2003·Breast Cancer Research and Treatment·Rumelia KorenRivka Gal
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