DcR1 expression in endometrial carcinomas.

Virchows Archiv : an International Journal of Pathology
Jordi TarragonaXavier Matias-Guiu

Abstract

The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family, which mediates apoptosis by the extrinsic pathway. Up-regulation of decoy receptors, DcR1 and DcR2, may result in diminished binding of TRAIL to their functional receptors. DcR1 expression was assessed in normal endometrial tissue (NE) and endometrial carcinoma (EC) samples by immunohistochemistry (IHC) and quantitative real-time polymerase chain reaction (PCR). IHC was performed in two tissue microarrays; one composed of 80 samples of NE and a second one constructed from paraffin-embedded blocks of 62 EC. For quantitative real-time RT-PCR analysis, RNA was obtained from 19 NE and 28 EC samples using Trizol. mRNA expression of DcR1 was assessed with Taqman-based assays in an Abi-Prism 700 SDS. Results were correlated with stage, histological type, and grade. By IHC, cytoplasmic expression of DcR1 was frequently seen in NE (79.6%) and varied according to the menstrual cycle. Positive DcR1 immunostaining was also detected in EC (98.1% of the cases) without any specific statistical association with histological type, grade, and stage. By quantitative real-time PCR, all NE had similar levels of DcR1expression (0.8-1.7 RQ), which were ...Continue Reading

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Citations

Jan 15, 2014·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Letícia da Conceição BragaAgnaldo Lopes da Silva Filho
Mar 22, 2014·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·L GottwaldA Jeziorski
Jul 3, 2013·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·L GottwaldA Jeziorski
May 5, 2012·Gynecologic Oncology·Letícia da Conceição BragaAgnaldo Lopes da Silva-Filho
Jul 6, 2018·Cell Communication and Signaling : CCS·François FabiEric Asselin

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